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Dietary intake of folate, vitamin B2, B6, B12 and the incidence of colorectal adenoma recurrence : a Dutch follow-up study

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Dietary intake of folate, vitamin B2, B6, B12 and the incidence of colorectal adenoma recurrence : a Dutch follow-up study

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Background: A high prevalence of colorectal cancer is found in the Western world. Colorectal adenoma is a well-established precursor for this disease and therefore plays an important role in colorectal cancer prevention. Recently, folate and B-vitamins (B2, B6, and B12, also known as riboflavin, pyridoxine and cobalamin, respectively) have emerged as important dietary factors that may influence colorectal neoplasia. Although the specific mechanism responsible for this assumption is not clearly identified yet, the folate mediated one-carbon metabolism appears to have a central role in this matter. This mechanism comprises of interrelated biochemical reactions that are involved in DNA synthesis and DNA methylation. Disturbances in these processes are thought to be involved in the pathogenesis of colorectal neoplasms. Despite of folate, other B-vitamins, functioning as cofactors, are critical in the one-carbon metabolism as well. Both epidemiological and interventional studies have reported about the possible preventive role of folate on colorectal neoplasia, while fewer studies about the role of other related B-vitamins on this topic have been conducted. Objective: This thesis investigated the association between dietary B-vitamins intake (i.e., folate, vitamin B2, vitamin B6 and vitamin B12) derived from foods and the incidence of colorectal adenoma recurrence in a Dutch population. Design: A prospective follow-up study was carried out in consequence of a case-control study (the POLIEP study) designed to investigate the association between dietary intake of folate, riboflavin, MTHFR C677T genotype and colorectal adenoma risk. Subjects of the current study (n=683) were cases from the POLIEP study with a history of colorectal adenoma and all underwent polypectomy. Dietary intake and lifestyle information was obtained through a food-frequency questionnaire and follow-up medical data was collected from gastroenterology and pathology reports. Baseline characteristics were then analyzed between the whole study population, the low, medium and high intake groups (designated by tertile cut points) of the four corresponding B-vitamins. A two-sided chi-square test (P-value less than 0.05 was considered significant) was conducted to assess the association between intake of these B-vitamins and the incidence of colorectal adenoma. Statistical analysis was performed using SPSS, version 16.0. Results: More men were prevalent among the study population (n= 361) and the overall average age was 59.1 (SD=10.1). The mean BMI of the total population was 26.2 kg/m2 (SD=3.8 kg/m2). The distribution of incidence of colorectal adenoma recurrence seems to be normal between the low, medium and high intake groups for all considering B-vitamins. No significant association has been found. Conclusions: The results from this follow-up study suggest that dietary intake of folate, vitamin B2, B6 and B12 has no association with the recurrence of colorectal adenomas. Further studies concentrating on the relation between dietary B-vitamins derived from food sources and the recurrence of colorectal adenomas are needed to draw a consistent conclusion.

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OrganisatieHogeschool van Amsterdam
InstituutBewegen, Sport en Voeding
Gepubliceerd in
Jaar2010
TypeBachelorscriptie
TaalEngels

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