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Clinical implications of overweight and obesity in chronic obstructive pulmonary disease

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Clinical implications of overweight and obesity in chronic obstructive pulmonary disease

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Objective: To examine the relationship between overweight-obesity in chronic obstructive pulmonary disease (COPD) and measures of body composition, lung function and dietary intake. Methods: 20 patients with COPD (11males, 9females) and 9 (6males, 3females) healthy subjects were studied. Body composition by Bioelectrical Impedance Analysis (BIA), Dual Energy X-Ray Absorptiometry (DXA) and Bioelectric Impedance Spectroscopy (BIS) was measured in all subjects. Lung function was measured by spirometry, expressed as Forced Expiratory Volume per second (FEV1). Dietary intake was determined using the 24 hour recall method. Body mass index (BMI) classes were defined by under/normal weight (BMI 18.5-25 kg/m2) and overweight/obese (BMI >28 kg/m2). Results: Weight, BMI, fat free mass index (FFMI), fat-mass (FM), fat mass index (FMI) and FM/FFM ratio of the whole body were significantly higher in overweight/obese COPD patients compared to under/normal weight COPD patients. Percentage lean body mass was significantly lower in overweight/obese COPD patients compared to under/normal weight COPD patients. Furthermore, abdominal FFMI, FM, FMI and FM/FFM ratio were significantly higher in overweight/obese COPD patients compared to under/normal weight COPD patients. Also, appendicular FM, FMI and FM/FFM ratio were significantly higher in overweight/obese COPD patients compared to under/normal weight COPD patients. Appendicular muscle mass index (ASMI) was higher in overweight/obese patients with severe COPD compared to under/normal weight patients with severe COPD. Abdominal FM/whole body FM ratio was significantly higher in overweight/obese COPD patients than in under/normal weight COPD patients. No difference in FEV1 was found between under/normal weight and overweight/obese COPD patients. Conclusion: Despite the fact that overweight/obese COPD patients have proportionally more fat mass which can negatively influence their lung function and systemic inflammation, the larger FFMI and ASMI have a positive effect on physical abilities, diffusion capacity and mortality. However, more research with larger populations is necessary to determine the exact clinical implications of overweight-obesity in COPD patients.

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OrganisatieHogeschool van Amsterdam
InstituutBewegen, Sport en Voeding
Gepubliceerd in
Jaar2011
TypeBachelorscriptie
TaalEngels

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