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Nutritional status, gastrointestinal functioning and quality of life of patients with locally advanced pancreatic cancer

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Nutritional status, gastrointestinal functioning and quality of life of patients with locally advanced pancreatic cancer

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Background & Aims: Although malnutrition is frequently described in patients with locally advanced pancreatic cancer (LAPC), little quantitative data is available on the nutritional status, gastrointestinal functioning and quality of life of these patients. Methods: Patients with LAPC included for experimental treatment by Irreversible Electroporation (IRE) were included. Weight loss in the past six months (kg), body mass index (BMI), nutritional intake (4-day diary), fat free mass index (FFMI), handgrip strength, resting energy expenditure by indirect calorimetry (REE) and gastro intestinal functioning measured by intestinal absorption capacity of energy and macronutrients (3-day feces collection and bomb calorimetry), exocrine pancreatic function by fecal elastase-1 (FE1), and quality of life (QoL) by the gastrointestinal quality of life index questionnaire, were measured before IRE. Results: Sixteen patients (50% male; mean age 60.3 ±9.5 years) were included. Median weight loss over the past 6 months amounted 10.1 kg [IQR 4.8 – 14.3], mean BMI was 23.9 ± 2.5 kg/m2. Energy and protein intake were 27 ±10 kcal/kg and 1.0 [±0.4] g/kg respectively. The minimum reference value of 25 kcal/kg/day was met by 67% of the patients. In 7 patients the FFMI and in 8 patients the handgrip strength was

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OrganisatieHogeschool van Amsterdam
InstituutBewegen, Sport en Voeding
Gepubliceerd in
Jaar2015
TypeBachelorscriptie
TaalEngels

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