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An investigation into delivery of theophylline for inhalation

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An investigation into delivery of theophylline for inhalation

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Samenvatting

Theophylline (TP) is a drug used to treat Chronic Obstructive Pulmonary Disease (COPD) and has been associated with multiple side effects, lessening its present use. This study aims to improve COPD treatment by creating a low-dose pressurized Metered Dose Inhaler (pMDI) and a Dry Powder Inhaler (DPI) formulation with theophylline (TP). Aerosol performance was assessed using Andersen Cascade Impaction (ACI) and Multi-stage liquid impinge (MSLI) for the DPI formulation. Morphology of the particles was analyzed with a Scanning Electron Microscope (SEM) and Calu-3 cell viability assay and cell transport were conducted to study the impact of the formulation on lung epithelial cells. The mass deposition profile of the formulation showed an emitted dose of 250.04 ± 14.48 µg per 5 actuations for the pMDI, achieving the designed nominal dose (50µg/dose). The aerosol performance of the DPI formulation showed an emitted dose of 3.2 ± 0,058 mg. SEM showed that the emitted particles of the pMDI were crystalline, spherical and hollow and the DPI particles were also spherical and crystalline but not hollow and the particles were bigger with a few clustered particles. Suitable solution pMDI and DPI formulations of TP were developed that could be used for the treatment of COPD.

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OrganisatieAvans Hogeschool
OpleidingBiologie en Medisch Laboratoriumonderzoek-Breda
AfdelingATGM Academie voor de technologie van Gezondheid en Milieu
PartnersWoolcock Institute of Medical Research
Datum2014-08-06
TypeBachelorscriptie
TaalEngels

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