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The determination of drugs in waste-water and soil samples by liquid chromatography and mass spectrometry.

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The determination of drugs in waste-water and soil samples by liquid chromatography and mass spectrometry.

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In the field of forensic science, the investigation of complex matrices for the determination of drug analytes by the multidiscipline environmental forensics involves a lot of different approaches such as; analytical chemistry, geochemistry, (eco) toxicology, statistics, chemical engineering and atmospheric chemistry. As with pharmaceuticals, also illicit drugs and metabolites of these compounds are eliminated through waste water [1]. Unfortunately these products are a rising problem as contaminants for the environment. The Department of Forensic Science & Drug Monitoring wants to optimise a research method that is possible for the identifying of drugs in complex matrices[2].
Water samples are collected in the London Thames in the vicinity of Europe's biggest water treating plant nearby Beckton. The water samples are examined with the analytical LC-ESI-MS/MS method to determine possible drugs. In order to prepare the water samples for LC-ESI-MS/MS determination, a method is optimised with the analytical methods such as liquid chromatography (LC)-UV detection and solid phase extraction. Preliminary results have shown, that with (LC)-UV detection drugs analytes can be detected in the μg/l range. During the solid phase extraction with a mixed mode cartridge, recovery percentages for different analytes lie between 13 to 102 % for 29 different pharmaceuticals. Also a separation method for soil is prepared by using an IKA Turax® homogenizing and grinding system.
Results with the LC-ESI-MS/MS has revealed that it is possible to determine drugs in water and sediment originating from the Thames. Now an optimised method has been established, it is important that a more extensive study is made during a longer period of time. With an extensive study, more analytes in different matrices can be determined in ng/L to μg/l concentrations.
Also the interdisciplinary use of the validated method will make it possible to affect different forensic approaches.

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OrganisatieAvans Hogeschool
AfdelingATGM Academie voor de technologie van Gezondheid en Milieu
PartnersKing's College London, School of Biomedical Sciences; Department of Forensic Science and Drug Monitoring, Analytical & Environmental Science Division
Datum2012-06
TypeBachelor
TaalEngels

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