De grootste kennisbank van het HBO

Inspiratie op jouw vakgebied

Vrij toegankelijk

Terug naar zoekresultatenDeel deze publicatie

The in vitro effects on the aerosol performance of poor lip sealing around the mouthpiece of pressurised metered dose inhalers

Rechten: Alle rechten voorbehouden

The in vitro effects on the aerosol performance of poor lip sealing around the mouthpiece of pressurised metered dose inhalers

Rechten: Alle rechten voorbehouden

Samenvatting

A problem associated with the use of pressurised metered dose inhalers (pMDI) is the inappropriate seal between a patient’s lips and the inhaler mouthpiece. Such incorrect use of the inhaler may affect its aerosol performance due to unpredicted changes of the flow dynamics in the inhaler. The current study investigates the in vitro aerosol performance of a commercial Ventolin® suspension pMDI and a beclomethasone dipropionate solution pMDI using cascade impaction method, at different experimental setup to simulate conditions where the correct/incorrect use of inhalers. In addition, effects of modified Ventolin® actuators, with high and low flow resistances, on the pMDI aerosol performances with the above configurations were also evaluated. This study demonstrated that different seal conditions with either a suspension or solution pMDIs did not significantly affect the aerosol performance of the formulation (p<0.05). No significant change (p<0.05) in fine particle dose was observed under different combinations of actuators and mouthpiece adaptors. The aerodynamic diameter and distribution of emitted particles from all experimental conditions did not show any significant change (p>0.05), probably due to the similar size of pre-engineered particles in the suspension formulation. It is hypothesized that the additional airflow induced by improper seals between patients’ lips and actuator mouthpiece may not influence the aerodynamic performance of suspension pMDIs. Resistance of air flowing through the actuator influenced particle deposition in the actuator mouthpiece and USP induction port, possibly due to different degree of flow turbulence at the exit of the actuator mouthpiece. However the particle deposition profiles in the cascade impactor did not exhibit any significant changes.

Toon meer
OrganisatieAvans Hogeschool
OpleidingBiologie en Medisch Laboratoriumonderzoek-Breda
AfdelingATGM Academie voor de technologie van Gezondheid en Milieu
PartnersWoolcock Institute of Medical Research Department: Respiratory Technology
Datum2014-08-01
TypeBachelor
TaalEngels

Op de HBO Kennisbank vind je publicaties van 26 hogescholen

De grootste kennisbank van het HBO

Inspiratie op jouw vakgebied

Vrij toegankelijk