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Endotoxemia-induced inflammation and the effect on the human brain

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Endotoxemia-induced inflammation and the effect on the human brain

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Samenvatting

Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described. Experimental endotoxemia (2 ng/kg Escherichia coli lipopolysaccharide [LPS]) was induced in 15 subjects, whereas 10 served as controls. Cytokines (TNF-α, IL-6, IL1-RA and IL-10), cortisol, brain specific proteins (BSP), electroencephalography (EEG) and cognitive function tests (CFTs) were determined.
Short-term systemic inflammation does not provoke or explain the occurrence of septic encephalopathy, but primarily results in an inflammation-mediated increase in cortisol and alertness.

OrganisatieHogeschool van Arnhem en Nijmegen
LectoraatAcute Intensieve Zorg
Gepubliceerd inCritical Care BioMed Central Ltd, Londen, Vol. 2010, Uitgave: 14, Pagina: R81
Jaar2010
TypeArtikel
ISSN1466-609X
TaalEngels

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