Is there a significant association between iron deficiency and physical activity in renal transplant recipients, and is this association independent of anemia?
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Is there a significant association between iron deficiency and physical activity in renal transplant recipients, and is this association independent of anemia?
Wij hanteren het label Open Access voor onderzoek met een Creative Commons licentie. Door een CC-licentie toe te kennen, geeft de auteur toestemming aan anderen om zijn of haar werk te verspreiden, te delen of te bewerken. Voor meer informatie over wat de verschillende CC-licenties inhouden, klik op het CC-icoon. Alle rechten voorbehouden wordt gebruikt voor publicaties waar enkel de auteurswet op van toepassing is.
Samenvatting
Background: Physical activity is a contributing factor to long-term survival after transplantation. Studies have shown that iron deficiency (ID) is an important determinant of lower levels of physical activity in healthy persons. Since ID is a modifiable factor, improvement in physical activity and subsequently survival could be obtained. To this date, it is unknown what the role of ID is on physical activity in renal transplant recipients (RTR). Within this cross-sectional study, we aimed to investigate whether there is a significant association between ID and physical activity in RTR, to be able to improve long-term survival after renal transplantation, and therefore healthy ageing, in RTR.
Methods: We analyzed data from the ‘TransplantLines’-study of the University Medical Center Groningen, The Netherlands. Blood pressure was measured according a standard protocol, and blood analyses were drawn using a standard laboratory protocol. Participants were examined using a composed Standard Operating Protocol (SOP), which included four physical tests, including the hand grip strength test, the 2-Minute Walk Test (2MWT), the Five Time Sit To Stand test (FTSTS) and the Timed Up and Go test (TUG). Univariate analyses, followed by multivariate stepwise backward linear regression, were used to analyze the predictive variables of physical activity in RTR.
Results: We included 128 RTR (age 55.6 ± 12.8; 56.3 % males). ID occurred in 47 RTR (37 %), anemia in 26 RTR (20 %). Mean hand grip strength was 33.9 ± 13.3 kg, 2MWT was 155.5 ± 53.1 meter, FTSTS was 12.4 ± 3.9 seconds and TUG was 6.9 ± 2.2 seconds. In linear regression analyses, ID was not significantly associated with all four physical tests.
Conclusions: We did not identify an association between iron status and physical activity in RTR. Remarkably, we did find a strong relationship between CRP and physical activity, suggesting that inflammation is detrimental for physical performance in this patient setting.
Organisatie | Hanzehogeschool Groningen |
Opleiding | Fysiotherapie |
Afdeling | Academie voor Gezondheidsstudies |
Jaar | 2017 |
Type | Bachelor |
Taal | Engels |