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Development of an IPK control system and oxygenator model

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Development of an IPK control system and oxygenator model

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Samenvatting

In order to better preserve donor kidney organs during and after procurement, the Universitary Medical Centre Groningen and partners are developing an improved Normothermic Regional Perfusion (NRP) device. Two main research objectives are to replace blood with a more efficient perfusion medium and to identify biochemical damage markers best indicative of kidney condition. To aid to this research a custom made Isolated Perfused Kidney (IPK) control system was requested. Furthermore additional research was performed on different oxygenators in order to create a model describing the process of oxygenation within an IPK setup.
The first section of this document contains research investigating the project domain and available hardware solutions currently being used during IPK. Furthermore the oxygenation process and which factors play a role in a membrane oxygenator were investigated. The second section entails development of an IPK control system and an oxygenator model based on multivariate polynomial regression.
The developed prototype IPK control system was able to pump a kidney at a desired pressure pattern and has been used in a multitude of IPK experiments. The developed model has an R2 value of 99, 88% with no sign of overfit and with every parameter adding a significant contribution.

Toon meer
OrganisatieHanzehogeschool Groningen
OpleidingAdvanced Sensor Applications
AfdelingHanze Institute of Technology
Jaar2016
TypeMaster
TaalEngels

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