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Genetics of post-nephrectomy residual renal capacity in living kidney donors

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Genetics of post-nephrectomy residual renal capacity in living kidney donors

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Samenvatting

Human kidneys have been shown to have a residual capacity, a compensation mechanism the kidney undergoes when the other kidney is lost or has lost its function. This thesis is aimed to find genetic variants associated with this capacity. This was done by correlating pre- and post-donation kidney function with genome-wide genotype data in living kidney donors. This measure is interpreted as the donor’s ability to adapt to single-kidney situation, a measure relevant for both the donor and recipient in kidney transplant situation. Significant association can increase knowledge of normal renal physiology and more specifically in the situation of unilateral nephrectomy.
Three loci were found to be significantly associated with the residual renal capacity. These loci are in the regions of gene PAX2, PAX3, and HLA-DRB6, which are logical functional candidates. Given the small sample size used in the study, independent studies should be conducted to replicate and validate these findings.

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OrganisatieHanzehogeschool Groningen
OpleidingMaster Sensor Technology
AfdelingHanze Institute of Technology
Jaar2016
TypeMaster
TaalEngels

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