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A novel method to identify changes in the optic radiation caused by glaucoma

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A novel method to identify changes in the optic radiation caused by glaucoma

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Samenvatting

This thesis investigates and proves a new
method that helps distinguish between the
optic radiations of a healthy brain and those
of a brain affected by glaucoma. This new
method uses fixel based analysis.
The hypothesis this thesis proves is that using
only the fixels that have the highest streamline
density per voxel in the optic radiation will
show a more significant difference than
using all fixels in the optic radiation (as was
done previously) because the fixels with
the highest streamline density are the most
likely to really be part of the optic radiation,
therefore it was expected that these fixels
would be more affected by glaucoma than
the other fixels. To prove this, a mask was
built that can filter out the unwanted fixels
for the right or the left optic radiation. Using
this filter on the fiber density files of each
subject gave significantly better results when
comparing the two groups than before with
all fixels in the optic radiations. The second,
third and fourth densest fixels were also
filtered out separately and analyzed. Most
of these showed no significant difference
between healthy subjects and glaucoma
patients, which makes sense, because when
using all fixels the difference is less, so the
fixels that do not have the highest streamline
density per fixel could be seen as noise.

Toon meer
OrganisatieHanzehogeschool Groningen
OpleidingMajor Sensor Technology
Datum2019-06-31
TypeMaster
TaalEngels

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