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Current challenges facing the assessment of the allergenic capacity of food allergens in animal models

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Current challenges facing the assessment of the allergenic capacity of food allergens in animal models

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From the article:
Abstract
Food allergy is a major health problem of increasing concern. The insufficiency of protein sources for human nutrition
in a world with a growing population is also a significant problem. The introduction of new protein sources into
the diet, such as newly developed innovative foods or foods produced using new technologies and production
processes, insects, algae, duckweed, or agricultural products from third countries, creates the opportunity for development
of new food allergies, and this in turn has driven the need to develop test methods capable of characterizing
the allergenic potential of novel food proteins. There is no doubt that robust and reliable animal models for the
identification and characterization of food allergens would be valuable tools for safety assessment. However, although
various animal models have been proposed for this purpose, to date, none have been formally validated as predictive
and none are currently suitable to test the allergenic potential of new foods. Here, the design of various animal
models are reviewed, including among others considerations of species and strain, diet, route of administration, dose
and formulation of the test protein, relevant controls and endpoints measured.

DOI: 10.1186/s13601-016-0110-2

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OrganisatieHogeschool Utrecht
AfdelingKenniscentrum Technologie en Innovatie
LectoraatInnovative Testing in Life Sciences and Chemistry
Gepubliceerd inClinical And Translational Allergy BioMed Central, London, Vol. 6, Pagina: 21
Datum2016-06-16
TypeArtikel
ISSN2045-7022
TaalEngels

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