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Zocht je misschien: drugs, druk?

Development of eHOME, a Mobile Instrument for Reporting, Monitoring, and Consulting Drug-Related Problems in Home Care

Nienke Dijkstra (Lid Lectoraat); Carolien Sino (Lid Lectoraat); Marieke Schuurmans (Lector); Rob Heerdink (Lector)

Home care patients often use many medications and are prone to drug-related problems (DRPs). For the management of problems related to drug use, home care could add to the multidisciplinary expertise of general practitioners (GPs) and pharmacists. The home care observation of medication-related problems …

2018-03-07GezondheidArtikel

Immune-related and adverse drug reactions to low versus high initial doses of Viscum album L. in cancer patients

Friedemann Schad (Onderzoeker); Anja Thronicke (Onderzoeker); Antje Merkle (Onderzoeker); Harald Matthes (Onderzoeker); Megan L. Steele (Onderzoeker)

Background: Immune-related adverse drug reactions (ADRs) to immunotherapy agents have been associated with beneficial clinical outcomes in oncology. Viscum album L. (VA, European mistletoe) is frequently used as an immunomodulatory agent alongside conventional cancer treatment in Europe. VA has been …

2017GezondheidArtikel

Community-based comprehensive lifestyle programs in patients with coronary artery disease: Objectives, design and expected results of Randomized Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists 2 trial (RESPONSE 2)

Lachman, Sangeeta; Minneboo, Madelon; Snaterse, Marjolein (Faculteit Gezondheid); Jorstad, Harald T.; ter Riet, Gerben; Scholte Op Reimer, Wilma J.; Boekholdt, S. Matthijs; Peters, Ron J.G.

Patients with coronary artery disease (CAD) are at high risk of recurrent events. A healthy lifestyle can significantly reduce this risk. A previous trial, Randomized Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists (RESPONSE), demonstrated that nurse-coordinated outpatient clinics …

2015-08AlgemeenArtikel

Quiet Please! Drug Round Tabards: Are They Effective and Accepted? A Mixed Method Study

Verweij, Lotte; Smeulers, Marian; Maaskant, Jolanda M.; Vermeulen, Hester

BACKGROUND: The use of drug round tabards is a widespread intervention that is implemented to reduce the number of interruptions and medication administration errors (MAEs) by nurses; however, evidence for their effectiveness is scarce. PURPOSE: Evaluation of the effect of drug round tabards on the frequency …

2014-09AlgemeenArtikel

Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer

Pennarun, Bodvaël; van der Heij-Meijer, Annemieke; de Vries, Elisabeth G.E.; Kleibeuker, Jan H.; Kruyt, Frank; de Jong, Steven

Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to its two pro-apoptotic receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2. Primary components of the DISC are trimerized …

2010-04-01AlgemeenAndersoortig materiaal

The influence of drug use on fall incidents among nursing home residents: a systematic review

C.S. Sterke; A.P. Verhagen; E. van Beeck; T.J.M. van der Cammen

Background: Falls are a major health problem among the elderly, particularly in nursing homes. Abnormalities of balance and gait, psychoactive drug use, and dementia have been shown to contribute to fall risk. Methods: We conducted a systematic review of the literature to investigate which psychoactive …

2008-04-17GezondheidArtikel

Target validation in silico

Alkema, Wynand; Rullmann, Ton; van Elsas, Andrea

Genomics has multiplied the number of targets for new therapeutic interventions, but this has not yet lead to a marked increase of pharma pipeline outputs. The complexity of protein function in higher order biological systems is often underestimated. Translation from in vitro and in vivo results to the …

2006-09-16AlgemeenArtikel

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