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Course of recovery of respiratory muscle strength and its associations with exercise capacity and handgrip strength: A prospective cohort study among survivors of critical illness

Major, Mel (Urban Vitality); van Egmond, Maarten (Lectoraat Fysiotherapie -Bewegen Naar Preventieve Zorg); Dettling-Ihnenfeldt, Daniela; Ramaekers, Stephan (Lectoraat Fysiotherapie -Bewegen Naar Preventieve Zorg); Engelbert, Raoul (Urban Vitality); van der Schaaf, Marike (Lectoraat Revalidatie Bij Complexe Zorg)

Background Mechanical ventilation affects the respiratory muscles, but little is known about long-term recovery of respiratory muscle weakness (RMW) and potential associations with physical functioning in survivors of critical illness. The aim of this study was to investigate the course of recovery of …

2023AlgemeenArtikel

The impact of high versus standard enteral protein provision on functional recovery following intensive care admission (PRECISE trial)

van Gassel, Rob J. J.; Bels, Julia L. M.; Tartaglia, Katrien; van Bussel, Bas C. T.; van Kuijk, Sander M. J.; Deane, Adam M.; Puthucheary, Zudin; Weijs, Peter J. M. (Lectoraat Voeding En Beweging); Vloet, Lilian; Beishuizen, Bert; De Bie Dekker, Ashley; Fraipont, Vincent; Lamote, Stoffel; Ledoux, Didier; Scheeren, Clarissa; De Waele, Elisabeth; van Zanten, Arthur R. H.; Mesotten, Dieter; van de Poll, Marcel C. G.

Background Critically ill patients are subject to severe skeletal muscle wasting during intensive care unit (ICU) stay, resulting in impaired short- and long-term functional outcomes and health-related quality of life. Increased protein provision may improve functional outcomes in ICU patients by attenuating …

2023AlgemeenArtikel

Practice of Awake Prone Positioning in Critically Ill COVID-19 Patients-Insights from the PRoAcT-COVID Study

We describe the incidence, practice and associations with outcomes of awake prone positioning in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) in a national multicenter observational cohort study performed in 16 intensive care units in the Netherlands (PRoAcT−COVID-study). …

2022-11-26AlgemeenArtikel

Practice of Awake Prone Positioning in Critically Ill COVID–19 Patients––insights from the PRoAcT–COVID study

Stilma, W. (Faculteit Gezondheid); Valk, C.; Van Meenen, D.; Schultz, M.; Paulus, F. (Lectoraat Critical Care)

Introduction It is unknown how awake prone positioning was practiced in patients with COVID–19 in the second wave of the national outbreak in the Netherlands. Objectives We studied the practice of awake prone positioning in COVID–19 patients admitted to the ICU because of acute hypoxemic respiratory …

2022-10-24AlgemeenConferentiebijdrage

The Use of Mechanical Insufflation-Exsufflation in Invasively Ventilated Critically Ill Adults

Swingwood, Ema L; Stilma, Willemke (Faculteit Gezondheid); Tume, Lyvonne N; Cramp, Fiona; Voss, Sarah; Bewley, Jeremy; Ntoumenopoulos, George; Schultz, Marcus J; Scholte Op Reimer, Wilma; Paulus, Frederique (Lectoraat Critical Care); Rose, Louise

Mechanical insufflation-exsufflation (MI-E) is traditionally used in the neuromuscular population. There is growing interest of MI-E use in invasively ventilated critically ill adults. We aimed to map current evidence on MI-E use in invasively ventilated critically ill adults. Two authors independently …

2022-08-01AlgemeenAndersoortig materiaal

Association between early cumulative fluid balance and successful liberation from invasive ventilation in COVID-19 ARDS patients - insights from the PRoVENT-COVID study

BACKGROUND: Increasing evidence indicates the potential benefits of restricted fluid management in critically ill patients. Evidence lacks on the optimal fluid management strategy for invasively ventilated COVID-19 patients. We hypothesized that the cumulative fluid balance would affect the successful …

2022-06-01AlgemeenArtikel

Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS

PRoVENT-COVID Study Group

Background: Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. Methods: Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is …

2021-12-01AlgemeenArtikel

Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome

PRoVENT-COVID

INTRODUCTION: Patients with COVID-19-related acute respiratory distress syndrome (ARDS) have been postulated to present with distinct respiratory subphenotypes. However, most phenotyping schema have been limited by sample size, disregard for temporal dynamics, and insufficient validation. We aimed to …

2021-12-01AlgemeenArtikel

Association of early positive end-expiratory pressure settings with ventilator-free days in patients with coronavirus disease 2019 acute respiratory distress syndrome

BACKGROUND : There is uncertainty about how much positive end-expiratory pressure (PEEP) should be used in patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). OBJECTIVE : To investigate whether a higher PEEP strategy is superior to a lower PEEP strategy …

2021-12AlgemeenArtikel

Differences in mortality in critically ill elderly patients during the second COVID-19 surge in Europe

COVIP Study Group

BACKGROUND: The primary aim of this study was to assess the outcome of elderly intensive care unit (ICU) patients treated during the spring and autumn COVID-19 surges in Europe. METHODS: This was a prospective European observational study (the COVIP study) in ICU patients aged 70 years and older admitted …

2021-09-23AlgemeenArtikel

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