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Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity

Seinen, Jolien; Engelke, Rudolf; Abdullah, Mohammed R; Voß, Franziska; Michalik, Stephan; Dhople, Vishnu M; Dieperink, Willem; de Smet, Anne Marie G A; Völker, Uwe; van Dijl, Jan Maarten; Schmidt, Frank; Hammerschmidt, Sven

Respiratory pathogens like Streptococcus pneumoniae can cause severe pneumonia. Nonetheless, mechanically ventilated intensive care patients, who have a high risk of contracting pneumonia, rarely develop pneumococcal pneumonia. Mechanically ventilated patients are at risk of contracting pneumonia. Therefore, …

2021-04-27AlgemeenArtikel

Decrease of physical fitness during neoadjuvant chemoradiotherapy predicts the risk of pneumonia after esophagectomy

Petra Bor; Feike Kingma; Ad Kerst; Elles Steenhagen; Jelle Ruurda; Richard van Hillegersberg; Karin Valkenet (Lid Lectoraat); Cindy Veenhof (Lector)

Although neoadjuvant chemoradiotherapy (nCRT) is frequently used in esophageal cancer patients undergoing treatment with curative intent, it can negatively impact patients’ physical fitness. A decline in physical fitness during chemoradiotherapy may be an indication of vulnerability. The aim of this …

2021GezondheidArtikel

Awake Proning as an Adjunctive Therapy for Refractory Hypoxemia in Non-Intubated Patients with COVID-19 Acute Respiratory Failure: Guidance from an International Group of Healthcare Workers

Stilma, Willemke (Faculteit Gezondheid); Åkerman, Eva; Artigas, Antonio; Bentley, Andrew; Bos, Lieuwe D.; Bosman, Thomas J. C.; de Bruin, Hendrik; Brummaier, Tobias; Buiteman-Kruizinga, Laura A.; Carcò, Francesco; Chesney, Gregg; Chu, Cindy; Dark, Paul; Dondorp, Arjen M.; Gijsbers, Harm J. H.; Gilder, Mary Ellen; Grieco, Domenico L.; Inglis, Rebecca; Laffey, John G.; Landoni, Giovanni; Lu, Weihua; Maduro, Lisa M. N.; McGready, Rose; McNicholas, Bairbre; de Mendoza, Diego; Morales-Quinteros, Luis; Nosten, Francois; Papali, Alfred; Paternoster, Gianluca; Paulus, Frederique (Lectoraat Critical Care); Pisani, Luigi; Prud'homme, Eloi; Ricard, Jean-Damien; Roca, Oriol; Sartini, Chiara; Scaravilli, Vittorio; Schultz, Marcus J.; Sivakorn, Chaisith; Spronk, Peter E.; Sztajnbok, Jaques; Trigui, Youssef; Vollman, Kathleen M.; van der Woude, Margaretha C. E.

Non-intubated patients with acute respiratory failure due to COVID-19 could benefit from awake proning. Awake proning is an attractive intervention in settings with limited resources, as it comes with no additional costs. However, awake proning remains poorly used probably because of unfamiliarity and …

2021AlgemeenArtikel

Effects of the application of a checklist during trauma resuscitations on ATLS adherence, team performance, and patient-related outcomes: a systematic review

Oscar van Maarseveen (Onderzoeker); Wietske Blom-Ham (Onderzoeker); Nils van de Ven (Onderzoeker); Tim Saris (Onderzoeker); Luke Leenen (Onderzoeker)

Purpose In this systematic literature review, the effects of the application of a checklist during in hospital resuscitation of trauma patients on adherence to the ATLS guidelines, trauma team performance, and patient-related outcomes were integrated. Methods A systematic review was performed following …

2020GezondheidArtikel

Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update

Karsten, Rebecca T.; van der Molen, Lisette; Hamming-Vrieze, Olga; van Son, RobJ. J. J. H.; Hilgers, Frans J. M.; van den Brekel, Michiel W. M.; Stuiver, Martijn M (Urban Vitality); Smeele, Ludi E.

BACKGROUND: The objective of this study was to explore the 10-year plus outcomes of Intensity Modulated Radiotherapy with concomitant chemotherapy (CRT) combined with preventive swallowing rehabilitation (CRT+) for head and neck cancer (HNC). METHODS: Subjective and objective swallowing, trismus, and …

2020AlgemeenArtikel

Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU

SUP-ICU trial group

BACKGROUND: Prophylaxis for gastrointestinal stress ulceration is frequently given to patients in the intensive care unit (ICU), but its risks and benefits are unclear. METHODS: In this European, multicenter, parallel-group, blinded trial, we randomly assigned adults who had been admitted to the ICU …

2018-12-06AlgemeenArtikel

Nursing home-acquired pneumonia, dysphagia and associated diseases in nursing home residents: A retrospective, cross-sectional study

Vanessa Hollaar; GJ van der Putten; CD Van der Maarel -Wierink; E.M. Bronkhorst; Bert de Swart; C de Baat; N.H.J. Creugers

2017AlgemeenArtikel

Changes in the in-hospital mortality and 30-day post-discharge mortality in acutely admitted older patients: retrospective observational study

van Rijn, Marjon; Buurman, Bianca M.; Macneil Vroomen, Janet L.; Suijker, Jacqueline J.; ter Riet, Gerben (Lectoraat Voeding En Beweging); Moll van Charante, Eric P.; de Rooij, Sophia E.

Objectives: to compare changes over time in the in-hospital mortality and the mortality from discharge to 30 days post-discharge for six highly prevalent discharge diagnoses in acutely admitted older patients as well as to assess the effect of separately analysing the in-hospital mortality and the mortality …

2016-01AlgemeenArtikel

Defining characteristics and risk indicators for diagnosing nursing home-acquired pneumonia and aspiration pneumonia in nursing home residents, using the electronically-modified Delphi Method

Vanessa Hollaar; C van der Maarel-Wierink; GJ van der Putten; W van der Sanden; B de Swart; C de Baat

2016AlgemeenArtikel

Effect of daily application of a 0.05% chlorhexidine solution on the incidence of (aspiration) pneumonia in care home residents: design of a multicentre cluster randomised controlled clinical trial.

Vanessa Hollaar; C van der Maarel-Wierink; GJ van der Putten; B de Swart; C de Baat

2015AlgemeenArtikel

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