The Centre for Higher Education Internationalisation (CHEI) was initiated by UCSC in 2011 to stimulate the enhancement and understanding of the internationalisation process and activities of Università Cattolica. This publication is the result of its first Seminar and by that also its first publication. The book is written by members of the Scientific Committee and Management Board of CHEI, and provides an informative introduction to the key issues and trends in higher education internationalisation in three parts. The first part deals with internationalisation, meaning and rationales, and includes three conceptual articles introducing the concept of internationalisation in the context of the global knowledge society we life in, as well as two chapters giving concrete examples of international strategies from Northern America. The second part deals with internationalisation of the curriculum and contains four chapters on different aspects of how to improve the internationalisation of our curriculum. In the final part of this book the focus is on internationalisation and Italian higher education. One chapter deals with the important question of how Italian employers value international education. Another chapter outlines a model of analysis of the drivers of inbound student mobility and considers the Italian case against other European countries. The third chapter discusses the current state of internationalisation at Università Cattolica within the context of higher education globalisation, indicating that to compete with outstanding universities at the global level, additional actions should be taken. The CHEI and this publication are intended to contribute to that objective.