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Fast selection of miRNA candidates based on large-scale pre-computed MFE sets of randomized sequences.

Fast selection of miRNA candidates based on large-scale pre-computed MFE sets of randomized sequences.

Samenvatting

Small RNAs are important regulators of genome function, yet their prediction in genomes is still a major computational challenge. Statistical analyses of pre-miRNA sequences indicated that their 2D structure tends to have a minimal free energy (MFE) significantly lower than MFE values of equivalently randomized sequences with the same nucleotide composition, in contrast to other classes of non-coding RNA. The computation of many MFEs is, however, too intensive to allow for genome-wide screenings.

OrganisatieHanzehogeschool Groningen
LectoraatLife Sciences & Renewable Energy
Gepubliceerd inBMC research notes Springer Verlag
Datum2014-01-13
TypeArtikel
ISSN1756-0500
TaalEngels

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