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Recent developments in basophil research

do basophils initiate and perpetuate type 2 T-helper cell responses?

Recent developments in basophil research

do basophils initiate and perpetuate type 2 T-helper cell responses?

Samenvatting

Basophils account for only 0.1-1% of all peripheral blood leukocytes. They were considered to be a redundant cell type for a long time. However, several findings show a non-redundant role for basophils in type 2 T-helper cell (Th2) immune responses in helminth infections, allergy and autoimmunity. Both immunoglobulin-E-dependent and -independent pathways have been described to contribute to basophil activation. In addition, several recent studies reported that basophils can function as antigen-presenting cells and are important in the initiation of Th2 immune responses. However, there are also conflicting studies that do not corroborate the importance of basophils in Th2 immune responses. This review discusses the role of basophils in Th2 immune responses in view of these recent findings.

OrganisatieHanzehogeschool Groningen
LectoraatBiobased Ingredients and Materials
Gepubliceerd inInternational Archives of Allergy and Immunology Karger Medical and Scientific Publishers, Vol. 160, Uitgave: 1, Pagina's: 7-17
Datum2013-01-01
TypeArtikel
ISSN1018-2438
DOI10.1159/000341633
TaalEngels

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