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Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation

Samenvatting

Background: The heat shock protein (HSP) inducer, geranylgeranylacetone (GGA), was previously found to protect against atrial fibrillation (AF) remodeling in experimental model systems. Clinical application of GGA in AF is limited, due to low systemic concentrations owing to the hydrophobic character of GGA. Objectives: To identify novel HSP-inducing compounds, with improved physicochemical properties, that prevent contractile dysfunction in experimental model systems for AF.

OrganisatieHanzehogeschool Groningen
LectoraatBiobased Ingredients and Materials
Gepubliceerd inDrug Design, Development and Therapy Dove Press Limited, Vol. 13
Datum2019-01-18
TypeArtikel
TaalEngels

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