Physiotherapists should take a primary role in relation to the prevention and management of all diseases that are associated with low levels of physical activity. The benefits of regular physical activity on health, longevity, and well being easily surpass the effectiveness of any drugs or other medical …

Background: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. Methods: We investigated whether acquired cisplatin resistance affects sensitivity to recombinant …

Doel: Het evalueren van de effectiviteit en veiligheid van het gebruik van bevacizumab (Avastin ®) bij prematurenretinopathie. Bevacizumab is een medicament dat is goedgekeurd door US Food en Drug Administration bij de behandeling van darm- en longkanker; het wordt off-label toegepast in de oogheelkunde. Methode: …

Het bedrijf Phytonics heeft het natuurlijke gezondheidsproduct, ‘‘Gluco balance’’ ontwikkeld, dat paarden met symptomen van insulineresistentie ondersteunt. Voor dit product wordt geclaimd, dat het de gevoeligheid van de insuline cel receptoren verbetert, en dat hiermee de insuline- en glucoseconcentraties …

The scientific literature represents a rich source for retrieval of knowledge on associations between biomedical concepts such as genes, diseases and cellular processes. A commonly used method to establish relationships between biomedical concepts from literature is co-occurrence. Apart from its use …

Organized crime differs substantially from high-volume crime, at least theoretically. But do offenders differ as well? This study makes an extensive comparison between offenders who engage in organized crime at a particular moment in their lives and general offenders, based on various dimensions of their …

BACKGROUND: Glucocorticoids (GCs) control expression of a large number of genes via binding to the GC receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although …

Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to its two pro-apoptotic receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2. Primary components of the DISC are trimerized …

This paper reviews how economic modelling provides a deeper understanding of drug markets. The exercise focuses on ‘soft drugs’ (cannabinoids) in the Netherlands and outlines the effects of prohibition and legalisation. The purpose is to present an overview of analytical tools to non-economists. Based …

Background: Falls are a major health problem among the elderly, particularly in nursing homes. Abnormalities of balance and gait, psychoactive drug use, and dementia have been shown to contribute to fall risk. Methods: We conducted a systematic review of the literature to investigate which psychoactive …