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Saturation mutagenesis reveals the importance of residues alphaR145 and alphaF146 of penicillin acylase in the synthesis of beta-lactam antibiotics

Jager, Simon A W; Shapovalova, Irina V; Jekel, Peter A; Alkema, Wynand B L; Svedas, Vytas K; Janssen, Dick B

Penicillin acylase (PA) from Escherichia coli can catalyze the coupling of an acyl group to penicillin- and cephalosporin-derived beta-lactam nuclei, a conversion that can be used for the industrial synthesis of beta-lactam antibiotics. The modest synthetic properties of the wild-type enzyme make it …

2008-01-01AlgemeenArtikel

Suffering Quantified? Feasibility and Psychometric Characteristics of 2 Revised Versions of the Pictorial Representation of Illness and Self Measure (PRISM)

PhD Ad J.J.M. Vingerhoets; PhD Marjet G.B.G. Blokhorst; MSc Jolene L.M. Reimus; MSc Annemieke M.A. van Nunen; MD Eveline J.M. Wouters (Lector)

The Pictorial Representation of Illness and Self Measure (PRISM) assesses suffering. In this article, the authors explored the feasibility and psychometric qualities of 2 revised versions of the PRISM-PRISM-R1 and PRISM-R2-that they used in 3 studies of participants with different medical problems. The …

2008GezondheidArtikel

A synthetic strategy for novel nonsymmetrical bola amphiphiles based on carbohydrates

Schuur, Boelo; Wagenaar, Anno; Heeres, André; Heeres, Erik H J

A number of novel nonionic bolaform amphiphiles with nonidentical aldityl head groups, 1-(1-deoxy-D-galactitol-1-ylamino)-6-(1-deoxy-D-glucitol-1-ylamino)hexane, 1-(1-deoxy-D-mannitol-1-ylamino)-6-(1-deoxy-D-glucitol-1-ylamino)hexane, and 1-(1-deoxy-D-galactitol-1-ylamino)-6-(1-deoxy-D-mannitol-1-ylamino)hexane …

2004-04-28AlgemeenArtikel

LINBAL, Light INterception By Active Leaflayers: Description and application of a Late Blight limited potato growth model for the Andean Ecoregion

Van Haren, RJF; Jansen, DM

The objective of this study is to apply a potato model for the Andean Ecoregion and extend this model with Late Blight epidemiology and fungicide spray scheduling in order to evaluate effects (trade-offs) of fungicide applications on potato yield.

2003AlgemeenArtikel

Functionele beschrijving van de gebruikersschermen en database-structuur van het beslissingsondersteunende systeem TIPS-Z

Kruise, A.; Jansen, D.M.; van Haren, Rob

2001AlgemeenWorkingpaper

Synthesis of α- and β-D-glucopyranuronate 1-phosphate and α-D-glucopyranuronate 1-fluoride: intermediates in the synthesis of D-glucuronic acid from starch

Heeres, André; Van Doren, Henk A.; Gotlieb, Kees F.; Bleeker, Ido Pieter

The title uronates were prepared by 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) catalysed sodium hypochlorite oxidation of α- and β-D-glucopyranosylphosphate (α-/β-Glc-1-P) and α-D-glucopyranosyl fluoride (α-Glc-1-F). Quantitative recovery of the TEMPO catalyst was achieved by azeotropic distillation …

1997-04-01AlgemeenArtikel

Analyses of the effects of potato cyst nematodes (Globodera pallida) on growth, physiology and yield of potato cultivars in field plots at three levels of soil compaction

Oijen, M van; Ruijter, F J; van Haren, Rob

Field experiments were carried out in 1991 and 1992 on sandy soil highly infested with the potato cyst nematode Globodera pallida. Half the trial area was fumigated with nematicide to establish two levels of nematode density. Three levels of soil compaction were made by different combinations of artificial …

1995-12-01AlgemeenArtikel

Asymmetric 1,3-dipolar cycloadditions to 5-(R)-menthyloxy-2(5H)-furanone

Rispens, Minze T.; Keller, Erik; de Lange, Ben; Zijlstra, Robert W.J.; Feringa, Ben L.

Various diazo compounds, nitrile oxides, nitrones and azomethine ylides were examined in 1,3-dipolar cycloadditions to enantiomerically pure 5-(R)-menthyloxy-2(5H)-furanone 1a. Pyrazoline 9 was obtained in 100% c.y. as a mixture of 2 diastereoisomers in ratios up to 72: 28, whereas pyrazoline 16 was …

1994AlgemeenArtikel

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