BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression …

Background: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. Methods: We investigated whether acquired cisplatin resistance affects sensitivity to recombinant …

Achtergrond Constraint Induced Aphasia Therapy (CIAT) is ontstaan uit de fysiotherapeutische behandeling Constraint Induced Movement Therapy (CIMT). CIAT is een zeer intensieve groepstherapie in spelvorm waarbij de deelnemers worden gedwongen verbaal te communiceren en compensatiestrategieën dienen te …

To investigate whether oxygen consumption and blood flow at rest and after exercise are lower in the affected arm of patients with repetitive strain injury (RSI) compared to controls, and lower in the healthy nonaffected forearm within patients with unilateral RSI. RSI is considered an upper extremity …

Crustaceans that are very common in streams were often used as the testing of water quality standards. Therefore, it is effective to select Crustaceans as an indicator to examine the influence of decreasing water flow. Climate change induced the extremely dry summer in the Netherlands. Water flow decrease …

BACKGROUND: Glucocorticoids (GCs) control expression of a large number of genes via binding to the GC receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although …

Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described. Experimental endotoxemia (2 ng/kg Escherichia coli lipopolysaccharide [LPS]) was induced in 15 subjects, whereas 10 served …

55 tot 75% van de overlevenden na een CVA ondervindt blijvende functionele beperkingen aan de bovenste extremiteit. Dit review behandelt de meest effectieve therapieën binnen de fysiotherapie. Het gaat om behandelingen waarin de patiënt wordt geactiveerd en waarin een rol voor de fysiotherapeut is weggelegd, …

Microfinance programs have significant potential for contributing towards improvements of agricultural and other rural sectors investments and operations and empowerments of rural community. However, access to financial institutions such as banks by smallholder farmers in rural areas is limited because …

Introduction: To reduce continuously increasing costs in drug development, adverse effects of drugs need to be detected as early as possible in the process. In recent years, compound-induced gene expression profiling methodologies have been developed to assess compound toxicity, including Gene Ontology …