Cyclophosphamide (CPA) is a commonly used alkylating chemotherapeutic drug that targets rapidly dividing cells causing apoptosis by crosslinking DNA. While effective against neoplasms, CPA can also affect healthy immune cells. This study investigated whether a single dose of CPA alters healthy lymphoid …

Purpose To investigate the test-retest reliability and validity of the steep ramp test (SRT), a short and practical maximal exercise test on a cycle ergometer, for assessing CRF in apparently healthy adults aged 25–85 years. Methods To determine test-retest reliability, the reliability group performed …

Background: Communicative participation is the most important outcome of speech and language therapy. Apatient-reported outcome measure (PROM) for children would help capture this outcome. Before this PROM can be developed, it is important to find out what situations children themselves find difficult …

Accurate and reliable decision-making in the criminal justice system depends on accurate expert reporting and on the correct interpretation of evidence by the judges, prosecutors, and defense lawyers. The present study aims to gain insight into the judiciary's capability to assess the accuracy and reliability …

BACKGROUND: Following a severe burn injury, individuals embark on a lifelong process of managing and integrating the physical, psychological, and social consequences, including functional limitations, fatigue, altered body image, and psychological trauma. To aid in this process, healthcare professionals …

Background The increasing demands of an aging population, healthcare workforce shortages, financial constraints, and a shift in care perspectives call for rethinking geriatric rehabilitation (GR). To ensure GR remains sustainable, a transition towards home-based GR is proposed, reducing the need for …

Circular, biobased, and modular construction practices are gaining traction as cities seek to reduce the environmental impact of the built environment. However, little is known about how these strategies affect construction logistics and their associated emissions. We develop an agent-based model to …

Intensive agriculture relies heavily on synthetic fertilizers, causing resource depletion and environmental issues such as nutrient leaching. Biogas liquid digestate offers a nutrient-rich byproduct from anaerobic digestors as a circular alternative source for plant nutrients in closed-loop. Within …

Cardamonin is a natural chalcone that has been extensively investigated for its anticancer activity. However, its clinical relevance is still not explicit, limiting its progression into clinical trials and highlighting a persistent gap between preclinical evidence and practical application. This review …

Existing observation instruments to measure differentiated instruction often lack insight into the degree to which teachers’ decisions match the actual needs of their students, and neglect the importance of preparation and evaluation. This article describes the psychometric evaluation of a comprehensive …