From TU Delft repository: "Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and …

doi: 10.1016/j.tiv.2017.11.005 / PMID:29155131

From the article: Abstract Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not induce putative preneoplastic …

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This short paper describes a workshop on “Establishing criteria for an independent 3R-index: Access to 3Rs” and the corporate responsibility of industry for the use of animals in testing. 28 August 2014 Prague, at the World Congress on Alternatives Animal Use in the Life Sciences

Deze publicatie beschrijft ervaringen met innnovatie in trajecten in de zorg en de bouw. Daarbij wordt gebruik gemaakt van de theorie van Peter Senge die complexe veranderingen in systeemdenken beschrijft. Deze Duurzame SysteemInnovatie/aanpak (DSI-aanpak) wordt beschreven met theoretische aanknopingspunten: …

This conference paper deals with various organizations and pilot initiatives regarding the theme of sustainability.

This article describes the final meeting for the program SLiM (Sneller van innovatie naar mens). In cooperation with the Netherlands Knowledge Centre on Alternatives to animal use (NKCA) an overview was given of the results on accelerated acceptance of Replacement, Refinement and Reduction (3R) of animals …

Despite changing attitudes towards animal testing and current legislation to protect experimental animals, the rate of animal experiments seems to have changed little in recent years. On May 15–16, 2013, the In Vitro Testing Industrial Platform (IVTIP) held an open meeting to discuss the state of the …

Interview met Cyrille Krul.