According to the "membrane sensor" hypothesis, the membrane's physical properties and microdomain organization play an initiating role in the heat shock response. Clinical conditions such as cancer, diabetes and neurodegenerative diseases are all coupled with specific changes in the physical state and …

This thesis describes how the abundance of CO2 a ects the porosity of H2O:CO2 ice mixtures deposited at di erent growth temperatures ranging from 30 - 70 K. The mixing ratios of the used ice samples H2O:CO2 = 10:1, 4:1 and 2:1 are of astrophysical relevance. Laser optical interference is used to monitor …

Already at diagnosis, head and neck cancer patients are at risk for malnutrition. Local symptoms such as swallowing problems are a major cause of malnutrition in these patients.1 Additionally, malnutrition may result from changes in smell and taste/aversion and loss of appetite. Presence of these systemic …

Previous research has shown clinical effectiveness of dermal substitution; however, in burn wounds, only limited effect has been shown. A problem in burn wounds is the reduced take of the autograft, when the substitute and graft are applied in one procedure. Recently, application of topical negative …

BACKGROUND: The employment of physician assistants (PAs) is a strategy to improve access to care. Since the new millennium, a handful of countries have turned to PAs as a means to bridge the growing gap between the supply and demand of medical services. However, little is known about this new workforce …

Thirty years ago, in the summer of 1982, I was introduced to pediatric nursing during my internship in the Sophia Children’s Hospital, Academic Hospital Rotterdam (now Erasmus MC). One of my unforgettable patients was Dirk, a 24-year-old man with cystic fibrosis (CF), who spent his time in hospital in …

Our conception of the brain is influenced by metaphors like the computer which grant the brain an executive function. This notion ignores the fact that the brain evolved in the context of the natural environment and functions together with it. In addition, we are frequently less aware of the action-perception …

ALIFE:The “as eaten” method to measure the Total Dietary Fibre content was implemented at the Hanze University of Applied Sciences (WP 4). The enzymatic treatment with the GtfB enzyme clearly resulted in an increased fibre content of starch from 1.6% to approx. 20% (fig A). When using this modified starch …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Patients treated with selective serotonin re‐uptake inhibitors (SSRIs) have been shown to have an increased risk of falling. In nursing homes, many patients with dementia are given SSRIs as a treatment for depression. In this group, however, the possible risk …

QUESTION: In adults who experience nocturnal leg cramps, does stretching of the calf and hamstring muscles each day just before sleep reduce the frequency and severity of the cramps? DESIGN: A randomised trial with concealed allocation and intention-to-treat analysis. PARTICIPANTS: Eighty adults aged …