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Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells

Stefan Vaessen (Lid Lectoraat); M.M.H. van Lipzig (Onderzoeker); Raymond Pieters (Lector); Cyrille Krul (Lector); Heleen Wortelboer (Onderzoeker); E. van de Steeg (Onderzoeker)

From TU Delft repository: "Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and …

2017GezondheidArtikel

Nutritional Supplement Use by Dutch Elite and Sub-Elite Athletes: Does Receiving Dietary Counseling Make a Difference?

F.C. Wardenaar; Ingrid Ceelen; Jan-Willem van Dijk; R.W. Hangelbroek; L. Van Roy; B. Van der Pouw; JHM de Vries; M. Mensink; R.F. Witkamp

The use of nutritional supplements is highly prevalent among athletes. In this cross-sectional study, we assessed the prevalence of nutritional supplement use by a large group of Dutch competitive athletes in relation to dietary counseling. A total of 778 athletes (407 males and 371 females) completed …

2017AlgemeenArtikel

Protein intake and clinical and functional outcome in ICU patients

Guadagni, M.; Streppel, M.T. (Lectoraat Voeding En Beweging); Schuurman, C.; Biolo, G.; Boirie, Y.; Rooijackers, O.; Kondrup, J.; Weijs, P.J.M. (Lectoraat Voeding En Beweging)

2017AlgemeenConferentiebijdrage

Protein turnover and metabolism in the elderly intensive care unit patient

Phillips, Stuart M.; Dickerson, Roland N.; Moore, Frederick A.; Paddon-Jones, Douglas; Weijs, Peter J. M. (Lectoraat Voeding En Beweging)

Many intensive care unit (ICU) patients do not achieve target protein intakes particularly in the early days following admittance. This period of iatrogenic protein undernutrition contributes to a rapid loss of lean, in particular muscle, mass in the ICU. The loss of muscle in older (aged >60 years) …

2017AlgemeenArtikel

SUN-P218 : Protein intake is associated with muscle injuries in circus athletes

Bouville, A.; van Rhenen, R.; Engberink, M.; Zijlstra, H.; van Rijn, R. V.; Weijs, P. (Lectoraat Voeding En Beweging); Stubbe, J.

2017AlgemeenArtikel

High prevalence of cachexia in newly diagnosed head and neck cancer patients: an exploratory study

Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Dijkstra, Pieter; Dijkstra, Gerard; Bijzet, Johan; Langendijk, Johannes A.; van der Laan, Bernard; Roodenburg, Jan

In patients with cancer, weight loss can be related to simple starvation, disturbed metabolism, or both. In patients with head and neck cancer (HNC), weight loss often is attributed to simple starvation because the obvious oral symptoms are known to hinder dietary intake. In this population, cachexia …

2017Gezondheid; …Artikel

Effect of a high protein diet and/or resistance exercise on the preservation of fat free mass during weight loss in overweight and obese older adults: a randomized controlled trial

Verreijen, Amely M; Engberink, Mariëlle F; Memelink, Robert G (Lectoraat Voeding En Beweging); van der Plas, Suzanne E (Faculteit Bewegen, Sport En Voeding); Visser, Marjolein; Weijs, Peter J M (Lectoraat Voeding En Beweging)

BACKGROUND: Intentional weight loss in obese older adults is a risk factor for accelerated muscle mass loss. We investigated whether a high protein diet and/or resistance exercise preserves fat free mass (FFM) during weight loss in overweight and obese older adults. METHODS: We included 100 overweight …

2017AlgemeenArtikel

A higher protein intake is not associated with 5-year change in mid-thigh muscle cross-sectional area by computed tomography in older adults

Verreijen, A.M.; Engberink, M.F.; Brouwer, I.A.; Cawthon, P.M.; Newman, A.B.; Tylavsky, F.A.; Harris, T.B.; Weijs, P.J.M. (Lectoraat Voeding En Beweging); Visser, M.

Rationale: A higher protein intake is suggested to preserve muscle mass during aging, and may therefore reduce the risk for sarcopenia. We explored whether the amount, type (animal/vegetable) and essential amino acid (EAA) composition of protein intake were associated with 5-year change in mid-thigh …

2017AlgemeenConferentiebijdrage

Bone mineral density is associated with muscle mass in obese older adults with diabetes type 2

Memelink, Robert G. (Lectoraat Voeding En Beweging); Verreijen, Amely M.; de Bos Kuil, Minse J.J. (Faculteit Bewegen, Sport En Voeding); Engberink, Mariëlle F.; Verlaan, Sjors; de Vogel-van den Bosch, Johan; Weijs, Peter J.M. (Lectoraat Voeding En Beweging)

Rationale: The number of obese older adults with diabetes type 2 is increasing worldwide. Weight loss treatment in this group seems beneficial for cardio-metabolic and other health outcomes, but it might reduce muscle mass and bone mineral density (BMD). The association between obesity and BMD is controversial, …

2017AlgemeenConferentiebijdrage

Validatie van een LC-MS/MS methode voor Tariquidar, Elacridar en een mengsel van substraten voor P-gp en Bcrp1 en toepassing voor in vivo farmacokinetiek studies

Nikkie Venekamp (Student)

Het NKI is een oncologisch onderzoekscentrum waar wetenschappelijk onderzoek gedaan wordt naar verschillende soorten kanker. Op de afdeling Bio-Farmacologie wordt er voornamelijk onderzoek gedaan naar geneesmiddelen, of een combinatie ervan, die hersentumoren bestrijden. Er worden in vitro en in vivo …

2016-11-25TechniekBachelor

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