The stability of upstream deposited tailings dams is dependent on maintaining a drawn down phreatic surface and unsaturated profile in its outer edge. However, it has been speculated that intense rainfall events could induce unexpected translation of pore air and water pressures into the tailings profile …

Recent years have seen a global rise in the failure of tailings dams. Studies investigating the causes of slope failure often recognise high intensity rainfall events to significantly contribute to liquefaction, erosion and overtopping. This study aims to investigate the influence of alternative physical …

Arrhythmogenic Cardiomyopathy (ACM), also known as arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a rare hereditary disease of the heart, where the connective, and fatty tissue is deposited in the muscle tissue of the ventricular myocardium primarily of the right but also left …

Background and aims: Observational data indicate that diets rich in fruits and vegetables have a positive effect on inflammatory status, improve metabolic resilience and may protect against the development of non-communicable diseases. Nevertheless, experimental evidence demonstrating a causal relationship …

Background The ROS1 G2032R mutation is the most common on-target resistance mutation in crizotinib treated ROS1-positive lung cancer patients. The aim of our study was to investigate resistance mechanisms in SCL34A2-ROS1G2032R positive Ba/F3 cells against second line treatment with lorlatinib. Methods …

Monitoring the Combined Effects of Induced Earthquakes and Climate Change on a Heritage Building in Groningen

''Heritage buildings are often subjected to loading conditions that they were not exposed to in their earlier life span. Induced earthquakes in non-seismic regions caused by energy exploitation activities, or strains in the ground that are caused by the climate changes, are new phenomena that alter the …

The intense impact of drought in Baidabo, Somalia, resulting in the displacement of millions of people, the loss of millions of livestock, and the unfortunate loss of thousands of lives, underscores the need to focus on understanding the drought preparedness of pastoralist communities in the region. …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …

Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the treatment of certain inflammatory diseases, total neutralization …