Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

Next-generation sequencing technology allows culture- independent analysis of species and genes present in a complex microbial community. Such metagenomics may overcome the inability to culture microbes in isolation. Microbial communities of interest are for example responsible for making biogas. Many …

Decentralized smart gas (energy) grid. Presentation given on the Energy Delta Convention PhD. Master Class 2012.

Young musicians at the conservatoire: talent or attainment? The mastery of a music instrument comes after many hours of practice: on the average 10,000. It should therefore be no surprise that most great musicians started their studies at an early age. Moreover, the technical achievement of playing a …

Our conception of the brain is influenced by metaphors like the computer which grant the brain an executive function. This notion ignores the fact that the brain evolved in the context of the natural environment and functions together with it. In addition, we are frequently less aware of the action-perception …

Er waait een nieuwe wind door het hoger onderwijs: studenten worden uitgedaagd hun talent te ontdekken en in te zetten om te komen tot bovengemiddelde prestaties. Een van de impulsen is de Topclass, een van de activiteiten uit het introductieprogramma daarvan is het TalentEvent. Het doel van ons onderzoek …

This final project has been assigned by ProDemos Huis voor Democratie en Rechtsstaat (House for Democracy and Rule of Law). This final project is a graduation paper for the bachelor degree European Studies from The Hague University of Applied Sciences. This benchmark research paper compares ProDemos …

Achtergrond: Het doel van deze studie is het evalueren van de aspecten van interbeoordelaarsbetrouwbaarheid van het PRPP-systeem (Perceive, Recall, Plan en Perform) van Taakanalyse voor het beoordelen van het dagelijks functioneren van thuiswonende patiënten met dementie. Methode: Video-opnames van 30 …

Chapter 2 in Impacts of Emerging Economies and Firms on International Business. One of the most remarkable phenomena of recent times is that a large number of firms from emerging economies have come to define and dominate new markets and enter the class of global innovation leaders. Firms that once specialized …

This paper explores how residents of Helmond Brandevoort, a neotraditional neighbourhood in the Netherlands, socially construct a 'classed' place identity and what role the historicised architecture plays within that process. Given that place identity is constructed through social and cultural practices, …