Objective To determine the association between physical activity (PA; duration and intensity) and patient and clinical outcomes at various measurement occasions post dysvascular major lower limb amputation (LLA). Methods In this multicenter longitudinal observational study, the PA levels of adults who …

Background Transitioning from paediatric to adult healthcare is a pivotal phase for adolescents and young adults (AYAs) with chronic conditions. Effective healthcare transition (HCT) supports continued healthcare engagement and stable psychosocial outcomes, reducing risks for patients, their families, …

This study aimed to develop a measurement instrument of frailty experiences, the Frailty Experiences Scale, in community-dwelling older adults and test its psychometric properties. The process involved three steps: expert sessions (n = 10) to assess face and content validity; think-aloud interviews (n = 5) …

The transition from adolescence to adulthood is a critical phase for young people living with perinatal HIV, who must navigate typical developmental milestones while managing a chronic illness and facing (fear of) societal stigma. This qualitative study explored the lived experiences of Dutch young adults …

Chronic nonspecific low back pain (CNSLBP) is a major problem and a leading cause of years lived with disability worldwide, with its burden expected to increase further. Disability represents a particularly important outcome in CNSLBP, as it is more strongly associated with reduced quality of life, work …

Abstract – Introduction: Depression is a common mental disorder with often persistent consequences. Even after adequate treatment, recovery may be far from optimal. To enhance outcomes, we aimed to identify and synthesize factors that depressed adults themselves perceived as facilitating or hindering …

During and in the aftermath of the COVID-19 crisis older people presented significantly reduced practice of physical activity and social contact and were exposed to several psychological stress factors that negatively affected physical and mental health. To change this for the better, the Erasmus+ project …

Globally, the COVID-19 pandemic has had a significant effect on people’s mental health and levels of physical activity, especially in older adults who are more vulnerable. Although it has been five years since the beginning of the COVID-19 pandemic, many older adults still face direct and indirect negative …

Objectives To assess the impact of BCG vaccination on systemic inflammation in neonates, focusing on sex-specific differences and the relationship between circulating inflammatory proteins and immune responses, including cytokine production and antibody levels. Methods A randomized clinical trial was …

As the global population continues to age, maintaining the physical performance and independence of older adults has become a critical public health concern. Population ageing describes a simultaneous increase in the number of older adults and the growth of the oldest- old demographic, which poses substantial …