The increasing prevalence of antimicrobial-resistant (AMR) bacteria in humans, animals, and the environment underscores the necessity for a rapid, sensitive, and specific method to identify resistance genes. Objectives: This study aims to develop a reliable detection tool for identifying the tetracycline-resistant …

Dit lesmateriaal is ontwikkeld in het kader van het BioClock-Consortium, een interdisciplinair onderzoeksproject waarin de wisselwerking tussen de biologische klok van mensen, planten en dieren en de wereld om ons heen centraal staat. In deze les leren leerlingen over het circadiane ritme door het maken …

We developed a lesson where students construct a qualitative representation to learn how clock genes are regulated. Qualitative representations provide a non-numerical description of system behavior, focusing on causal relation-ships and system states. They align with human reasoning about system dy-namics …

Deze presentatie neemt je mee in de basisarchitectuur van Large Language Models en laat zien hoe Fenna Feenstra en Wynand Alkema samen met studenten een BERT‑model hebben ontwikkeld om longceltypes te annoteren. Ten slotte bespreken ze de bredere impact van LLM’s op het vakgebied en de kansen die ze …

Protein kinases function as pivotal regulators in biological events, governing essential cellular processes through the transfer of phosphate groups from ATP molecules to substrates. Dysregulation of kinase activity is frequently associated with cancer, ocasionally arising from chromosomal translocation …

Hereditary Breast and Ovarian Cancer (HBOC) typically arises from mutations inherited in the germline. BRCA1 and BRCA2 mutaions are predominant contributors to HBOC, accounting for the majority of cases. These mutations are associated with 10% of ovarian cancer cases and 3-5% of breast cancer cases [4]. BRCA1 …

The concept of biodiversity, which usually serves as a shorthand to refer to the diversity of life on Earth at different levels (ecosystems, species, genes), was coined in the 1980s by conservation biologists worried over the degradation of ecosystems and the loss of species, and willing to make a case …

Alzheimer's disease (AD) is the common neurodegenerative disorder and the most frequent cause of dementia. The disease accounts around 80% of all dementia diagnoses. The main reason of developing AD is amyloid cascade which starts from missense mutations in APP (amyloid precursor protein), Rho-associated …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …