Cardamonin is a natural chalcone that has been extensively investigated for its anticancer activity. However, its clinical relevance is still not explicit, limiting its progression into clinical trials and highlighting a persistent gap between preclinical evidence and practical application. This review …

Multi-layer cell constructs produced in vitro are an innovative treatment option to support the growing demand for therapy in regenerative medicine. Our research introduces a novel construct integrating organ-derived decellularised extracellular matrix (dECM) hydrogels and 3D-printed biodegradable polymer …

Presentatie van de eerste resultaten van de in vivo studies met vleeskuikens waarin gestreefd wordt naar een meer duurzame en diervriendelijke pluimveehouderij, tijdens de European Poultry Conference (EPC) in Valencia.

Spasticiteit is een aandoening welke invloed heeft op de spiercontrole. Wereldwijd kampen 12 miljoen mensen met spasticiteit (Spasticity, 2021). De cliënte is een van deze 12 miljoen mensen. De aanleiding van dit ontwikkelproject is dan ook de hulpvraag van deze mevrouw om haar nachtelijk spasmes draagbaarder …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …

Developmental Transformations (DvT), a practice involving interactive, improvisational play in pairs or groups, has gained international appeal as a therapeutic intervention for different populations in a variety of health, care and recreational contexts. However, a rigorous review of the benefits of …

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R- …

The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) …

Background Physical exercise is an intervention that might protect against doxorubicin‐induced cardiotoxicity. In this meta‐analysis and systematic review, we aimed to estimate the effect of exercise on doxorubicin‐induced cardiotoxicity and to evaluate mechanisms underlying exercise‐mediated cardioprotection …

Prostaatkanker is wereldwijd de op één na meest voorkomende vorm van kanker bij mannen (Bray, et al., 2018). In Nederland blijkt dit bij mannen boven de 45 jaar zelfs de meest voorkomende vorm van deze ziekte te zijn (Gommer & Poos, 2020). Voor de behandeling van prostaatkanker wordt regelmatig inwendige …