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Feasibility Study to Assess Canagliflozin Distribution and Sodium-Glucose Co-Transporter 2 Occupancy Using [18F]Canagliflozin in Patients with Type 2 Diabetes

van der Hoek, Sjoukje; Willemsen, Antoon T.M.; Visser, Ton; Heeres, Andre; Mulder, Douwe J.; Bokkers, Reinoud P.H.; Slart, Riemer H.J.A.; Elsinga, Philip H.; Heerspink, Hiddo J.L.; Stevens, Jasper

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, including canagliflozin, reduce the risk of cardiovascular and kidney outcomes in patients with and without type 2 diabetes, albeit with a large interindividual variation. The underlying mechanisms for this variation in response might be attributed …

2023-03-10AlgemeenArtikel

A framework to improve qualityof hospital-based physiotherapy

Steenbruggen, (Rudi) (Onderzoeker); Brand, (Paul) (Extern); Maas, (Marjo) (Extern); Hoogeboom, T.J. (Thomas) (Extern); Wees, P.J. (Philip) van der (Extern)

2023-01-01AlgemeenArtikel

Studying Telmisartan Plasma Exposure, Kidney Distribution, Receptor Occupancy, and Response in Patients With Type 2 Diabetes Using [11C]Telmisartan

van der Hoek, Sjoukje; Mulder, Douwe J.; T.M. Willemsen, Antoon; Visser, Ton J.; Heeres, André; Slart, Riemer H.J.A.; Elsinga, Philip H.; Heerspink, Hiddo J. L.; Stevens, Jasper

The angiotensin receptor blocker telmisartan slows progression of kidney disease in patients with type 2 diabetes (T2D), yet many patients remain at high risk for progressive kidney function loss. The underlying mechanisms for this response variation might be attributed to differences in angiotensin-1 …

2022-09-07AlgemeenArtikel

Development and internal validation of a machine learning prediction model for low back pain non-recovery in patients with an acute episode consulting a physiotherapist in primary care

Hoogeboom, T.J. (Thomas) (Phd); Lankveld, W. (Wim) van (Phd); Knoop, J (Jesper) (Phd); Hoppenbrouwers, S. (Stijn) (Phd); Heymans, M.W. (M.) (Phd); Overmeeren, E. (Elon) van (Extern); Veenhof, C. (Cindy) (Lector); Sappelli, M. (Maja) (Onderzoeker); Wees, P.J. (Philip) van der (Professor); Soer, (Remko) (Associate Lector); Beijer, ( Lilian) (Extern); Geerdink, (Frank) (Onderzoeker); Vissers, (Kris) (Extern); Staal, (Bart) (Extern); Mittendorff, ( Kariene ) (Associate Lector); Holkenborg, (Kris)

Background While low back pain occurs in nearly everybody and is the leading cause of disability worldwide, we lack instruments to accurately predict persistence of acute low back pain. We aimed to develop and internally validate a machine learning model predicting non-recovery in acute low back pain …

2022-09-01AlgemeenArtikel

Evaluation of allied healthcare in patients recovering from Covid-19

Rob A. de Bie (Onderzoeker); Arie C. Verburg (Onderzoeker); Carla Agasi-Idenburg (Onderzoeker); Edith H.C. Cup (Onderzoeker); Carolien Dekker (Onderzoeker); Johanna M. van Dongen (Onderzoeker); Edwin Geleijn (Onderzoeker); Marissa H.G. Gerards (Onderzoeker); Maud Graff (Onderzoeker); Ron van Heerde (Onderzoeker); Hanneke Kalf (Onderzoeker); Marly Kammerer (Onderzoeker); Renée A. Kool (Onderzoeker); Anja de Kruif (Onderzoeker); Hinke M. Kruizenga (Onderzoeker); Marike van der Leeden (Onderzoeker); Ton A.F. Lenssen (Onderzoeker); Willemijn M. Meijer (Onderzoeker); Raymond Ostelo (Onderzoeker); Amber Ronteltap (Onderzoeker); Marike van der Schaaf (Onderzoeker); Sonja van Oers (Onderzoeker); Marian A. E. de van der Schueren (Onderzoeker); Anne I. Slotegraaf (Onderzoeker); Cindy Veenhof (Lector); Thomas J. Hoogeboom (Onderzoeker); Philip J. van der Wees (Onderzoeker)

Objective: To report the study protocol and baseline characteristics of a prospective cohort study to evaluate longitudinal recovery trajectories of patients recovering from COVID-19 who have visited a primary care allied health professional. Design: Report of the protocol and baseline characteristics for …

2022GezondheidArtikel

GMP Compliant Synthesis of [18F]Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Heeres, André; Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium–glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

Heeres, André; van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

Investigation on what the preferred marketing strategy is to attract the German tourist

Philip Leutscher (Student); Maurice Chia (Begeleider)

This study showcases in depth research on how a boutique hotel in Rotterdam can attract the German tourist more effectively.

2021Mens & MaatschappijBachelor

The need to integrate flood and drought disaster risk reduction strategies

Ward, Philip J.; de Ruiter, Marleen C.; Mard, Johanna; Schröter, Kai; van Loon, Anne; Veldkamp, Ted (Lectoraat Klimaatbestendige Stad); von Uexkull, Nina; Wanders, Niko; AghaKouchak, Amir; Arnbjerg-Nielsen, Karsten; Capewell, Lucinda; Carmen Llasat, Maria; Day, Rosie; Dewals, Benjamin; Di Baldassare, Giuliano; Huning, Laurie S.; Kreibich, Heidi; Mazzoleni, Maurizio; Savelli, Elisa; Teutschbein, Claudia; van den Berg, Harmen; van der Heijden, Anne; Vincken, Jelle M.R.; Waterloo, Maarten J.; Wens, Marthe

Most research on hydrological risks focuses either on flood risk or drought risk, whilst floods and droughts are two extremes of the same hydrological cycle. To better design disaster risk reduction (DRR) measures and strategies, it is important to consider interactions between these closely linked phenomena. …

2020-12AlgemeenArtikel

Global River discharge and floods in the warmer climate of the last interglacial

Scussolini, Paolo; Eilander, Dirk; Sutanudjaja, Edwin H.; Ikeuchi, Hiroaki; Hoch, Jannis M.; Ward, Philip J.; Bakker, Pepijn; Otto-Bliesner, Bette; Guo, Chuncheng; Stepanek, Christian; Zhang, Qiong; Braconnot, Pascale; Guarino, Maria-Vittoria; Muis, Sanne; Yamazaki, Dai; Veldkamp, Ted I.E. (Lectoraat Klimaatbestendige Stad); Aerts, Jeroen C.J.H.

We investigate hydrology during a past climate slightly warmer than the present: the last interglacial (LIG). With daily output of preindustrial and LIG simulations from eight new climate models we force hydrological model PCR‐GLOBWB and in turn hydrodynamic model CaMa‐Flood. Compared to preindustrial, …

2020-09-28AlgemeenArtikel

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