It is estimated that over 30,000 lesions in the DNA are generated per cell per day. In S-phase, lesions in the DNA can stall replication, which can lead to secondary lesions such as DNA double- strand breaks. The DNA damage tolerance (DDT) network enables replication to be continued in the presence of …

Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out …

Introduction In the harbor of Zierikzee there is a strong tidal influence. The difference between the water levels during high and low tide lies around the three meters. The harbors De Oude Haven and ‘T Sas fall dry during an extremely low tide. When these harbors fall dry, foundations will come in …

Metformin prevents weight gain in patients with type 2 diabetes (T2D). However, the mechanisms involved are still unknown. In this post hoc analysis of the HOME trial, we aimed to determine whether metformin affects energy intake. Patients with T2D were treated with 850 mg metformin or received placebo …

Recent studies show that charging stations are operated in an inefficient way. Due to the fact that electric vehicle (EV) drivers charge while they park, they tend to keep the charging station occupied while not charging. This prevents others from having access. This study is the first to investigate …

In recent years, the recognition of the importance of ecosystem services provided by peatlands has become increasingly topical (Clarke, 2006). It is now known that peatland degradation and loss of habitat has large negative impacts, particularly with regards the loss of the habitats natural carbon sink …

The ‘pay gap’ is a relatively new term. However, it is a problem that was developed around the beginning of the 20th century, the moment when women were allowed to hold a paid occupation in the Netherlands and Norway. The pay gap, often confused with unequal pay for the same work, is actually a complex …

This study is intended to offer an insight into the difficulties experienced by the nation-state in its policy response to asylum and to determine whether there is a post-national solution. Processes of globalization accompanied by war and conflicts, increased migration flows of refugees, and a growing …

Since its founding in 1948, North Korea has consistently been connected to committing crimes against humanity. The non-interventionist policies that were prevalent throughout the Cold War protected it from outside intervention. Indeed, any country could do as they pleased within its borders as state-sovereignty …

In this paper the design and development of a new type of greenhouse with an integrated filter for reflecting near infrared radiation (NIR) and a solar energy delivery system is described. Especially the optical parts as the spectral selective film, the properties of the circular reflector and the efficiencies …