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Nanomaterials and the Serosal Immune System in the Thoracic and Peritoneal Cavities

Friede Kuper (Onderzoeker); Raymond Pieters (Lector); Jolanda van Bilsen (Onderzoeker)

The thoracic and peritoneal cavities are lined by serous membranes and are home of the serosal immune system. This immune system fuses innate and adaptive immunity, to maintain local homeostasis and repair local tissue damage, and to cooperate closely with the mucosal immune system. Innate lymphoid cells …

2021GezondheidArtikel

Diagnostic profiles for precision medicine in systemic sclerosis

Smeets, Ruben L.; Kersten, Brigit E.; Joosten, Irma; Kaffa, Charlotte; Alkema, Wynand; Koenen, Hans J.P.M.; Vonk, Madelon C.

Systemic sclerosis (SSc) is an autoimmune disease which is characterized by vasculopathy, tissue fibrosis and activation of the innate and adaptive immune system. Clinical features of the disease consists of skin thickening and internal organ involvement. Due to the heterogeneous nature of the disease …

2020-05-01AlgemeenArtikel

Chromosomal resolution reveals symbiotic virus colonization of parasitic wasp genomes

Gauthier, J.; Boulain, H.; Vugt, J.F.A. van; Baudry, L.; Boer, J.G. de (Lector)

Most endogenous viruses, an important proportion of eukaryote genomes, are doomed to slowly decay. Little is known, however, on how they evolve when they confer a benefit to their host. Bracoviruses are essential for the parasitism success of parasitoid wasps, whose genomes they integrated ~103 million …

2020Natuur & LandbouwArtikel

Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study

Liberman, Keliane; Njemini, Rose; Luiking, Yvette; Forti, Louis N.; Verlaan, Sjors; Bauer, Jürgen M.; Memelink, Robert (Faculteit Bewegen, Sport En Voeding); Brandt, Kirsten; Donini, Lorenzo; Maggio, Marcello; Mets, Tony; Weijers, Sander L.J.; Sieber, Cornel; Cederholm, Tommy; Bautmans, Ivan

Background: A chronic low-grade infammatory profle (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for efects of nutritional supplementation on CLIP is limited. Aim To investigate whether 13 weeks of nutritional supplementation …

2019-06AlgemeenArtikel

Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection

Paul G. Werthmann (Onderzoeker); Pia Inter (Onderzoeker); Thilo Welsch (Onderzoeker)

Rationale: Metastatic pancreatic cancer has a dismal prognosis. Many patients seek integrative care as an add-on to their conventional cancer treatment. Viscum album extracts (VAE)—widely used as an adjunct to cancer treatment—have cytotoxic, apoptogenic, and immune stimulatory properties. A statistically …

2018-10-22GezondheidArtikel

Release of major peanut allergens from their matrix under various pH and simulated saliva conditions—Ara h2 and ara h6 are readily bio-accessible

Stef J. Koppelman (Onderzoeker); Mieke Smits (Lid Lectoraat); Monic Tomassen (Onderzoeker); Govardus A.H. de de Jong (Onderzoeker); Joe Baumert (Onderzoeker); Steve L. Taylor (Onderzoeker); Renger Witkamp (Onderzoeker); Robert Jan Veldman (Lid Lectoraat); Raymond Pieters (Lector); Harry Wichers (Onderzoeker)

from the article: "Abstract: The oral mucosa is the first immune tissue that encounters allergens upon ingestion of food. We hypothesized that the bio-accessibility of allergens at this stage may be a key determinant for sensitization. Light roasted peanut flour was suspended at various pH in buffers …

2018-09-11GezondheidArtikel

Dietary Supplementation with Nondigestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

Laura Wagenaar (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Giulio Giustarini (Onderzoeker); Marlotte M. Vonk (Onderzoeker); Betty C.A.M. van Esch (Onderzoeker); Léon M.J. Knippels (Onderzoeker); Johan Garssen (Onderzoeker); Joost Smit (Onderzoeker); Raymond Pieters (Lector)

Abstract 1 Scope A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support …

2018-08-13GezondheidArtikel

A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment

Paul G. Werthmann (Onderzoeker); Lothar Kindermann (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Background Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating …

2018-04-09GezondheidArtikel

Glycation of the Major Milk Allergen β-Lactoglobulin Changes Its Allergenicity by Alterations in Cellular Uptake and Degradation

Marija Perusko (Onderzoeker); Manon van Roest (Onderzoeker); Dragana Stanic-Vucinic (Onderzoeker); Peter J. Simons (Onderzoeker); Raymond Pieters (Lector); Tanja Cirkovic-Velickovic (Onderzoeker); Joost Smit (Onderzoeker)

From the article: "Scope: During food processing, the Maillard reaction ( М R) may occur, resulting in the formation of glycated proteins. Glycated proteins are of particular importance in food allergies because glycation may influence interactions with the immune system. This study compared native …

2018GezondheidArtikel

Clinical safety of combined therapy of immune checkpoint inhibitors and Viscum album L. therapy in patients with advanced or metastatic cancer

Anja Thronicke (Onderzoeker); Megan L. Steele (Onderzoeker); Christian Grah (Onderzoeker); Burkhard Matthes (Onderzoeker); Friedemann Schad (Onderzoeker)

Background: Despite improvement of tumour response rates in patients with progressive and metastatic cancer, immune checkpoint inhibitors (ICM) induce toxicities in cancer patients. Viscum album L. (VA, mistletoe) extracts are applied as add-on cancer therapy especially in German speaking countries and …

2017-12-13GezondheidArtikel

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