Nicotine is a well-known and highly addictive substance with complex effects on cognition, anxiety, and neurophysiology. Despite its short-term anxiolytic effects, this drug often exacerbates anxiety symptoms. It disrupts emotional regulation through its impact on the central nucleus of the amygdala …

This research report presents the development of a 5- to 7-day incentive program in Bulgaria for World Synergy Travel (WST), a leading tour operator and a provider of leisure travel programs in the country. It also underscores the growing interest in incentive travel and the potential for Bulgaria, an …

Obesity is a growing global burden with numerous significant health implications, including a higher risk of developing Alzheimer’s disease (AD). This study investigates the role of obese adipose tissue on AD pathology in male APPswe/PSEN1-dE9 (APP/PSEN-1) transgenic mice, with a focus on cognitive decline, …

Brain disorders, such as Alzheimer’s disease and epilepsy have been linked to an imbalance in excitatory and inhibitory (E/I) inputs in the brain. However, the molecular mechanisms underlying E/I balance and plasticity in the brain are largely unresolved. Inhibitory synapses have a strong impact on brain …

Dit artikel is een op uitnodiging van het tijdschrift Acta Physiologica geschreven "Editorial" over het proeven van vetzuren door zoogdieren. Het artikel refereert naar een studie van Nagai et al. dat in juli 2025 in Acta Physiologica verscheen onder de titel “Fatty Acid Taste Quality Information via …

Alzheimer's disease is a complex neurodegenerative disease and the most prevalent form of dementia. It affects every 14th person after the age of 65, thus making it a serious concern in modern society. Furthermore, currently available treatment is restricted only to symptomatic and is not highly effective. …

Over time memories are believed to undergo a time-dependent reorganization in the brain through a process known as systems consolidation during which they become less dependent on the hippocampus and more dependent on the neocortical structures. This reorganization is accompanied by a generalization …

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

Dit rapport is geschreven voor Postillion hotel Deventer ten behoeve van de opstart van de lokale marketing en is de verantwoording van het opgestelde Instagramplan met bijbehorende contentkalender. Postillion hotel Deventer is een hotel dat zich de expert noemt op het gebied van vergaderingen en meetings …

It is estimated that over 30,000 lesions in the DNA are generated per cell per day. In S-phase, lesions in the DNA can stall replication, which can lead to secondary lesions such as DNA double- strand breaks. The DNA damage tolerance (DDT) network enables replication to be continued in the presence of …