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DARTpaths, an in silico platform to investigate molecular mechanisms of compounds

Diksha Balla (Onderzoeker); Marvin Steijaert (Onderzoeker); Eefje Poppelaars (Onderzoeker); Marc Teunis (Onderzoeker); Monique van der Vloet (Onderzoeker); Marie Corradi (Onderzoeker); Elisabeth Dévière (Onderzoeker); Luuk Noothout (Onderzoeker); Wilco Tomassen (Onderzoeker); Martijn Rooseboom (Onderzoeker); Richard Currie (Onderzoeker); Cyrille Krul (Lector); Raymond Pieters (Lector); Vera van Noort (Onderzoeker); Marjolein Wildwater (Onderzoeker)

Summary: Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating phenotypic endpoints of different species; and proposes follow-up tests for model organisms to validate these pathway predictions. The Xpaths algorithms are applied …

2023GezondheidArtikel

Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes

Monique van der Voet (Onderzoeker); Marc Teunis (Associate Lector); Johanna Louter-Van de Haar (Onderzoeker); Nienke Stigter (Onderzoeker); Diksha Balla (Onderzoeker); Martijn Rooseboom (Onderzoeker); Kimberley Wever (Onderzoeker); Cyrille Krul (Lector); Raymond Pieters (Lector); Marjolein Wildwater (Onderzoeker); Vera van Noort (Onderzoeker)

Implementation of reliable methodologies allowing Reduction, Refinement, and Replacement (3Rs) of animal testing is a process that takes several decades and is still not complete. Reliable methods are essential for regulatory hazard assessment of chemicals where differences in test protocol can influence …

2021GezondheidArtikel

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DARTpaths, an in silico platform to investigate molecular mechanisms of compounds

Towards a reporting guideline for developmental and reproductive toxicology testing in C. elegans and other nematodes

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