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Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

Jean Paul ten Klooster (Onderzoeker); Marianne Bol-Schoenmakers (Onderzoeker); Kitty van Summeren (Onderzoeker); Arno van Vliet (Onderzoeker); Cornelis de Haan (Onderzoeker); Frank van Kuppeveld (Onderzoeker); Saertje Verkoeijen (Onderzoeker); Raymond Pieters (Lector)

IL22 is an important cytokine involved in the intestinal defense mechanisms against microbiome. By using ileum-derived organoids, we show that the expression of anti-microbial peptides (AMPs) and anti-viral peptides (AVPs) can be induced by IL22. In addition, we identified a bacterial and a viral route, …

2021GezondheidArtikel

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Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine

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