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The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands

Sealy, Martine J (Healthy Ageing, Allied Health Care And Nursing); van Vliet, Iris M Y (Healthy Ageing, Allied Health Care And Nursing); Jager-Wittenaar, Harriët (Healthy Ageing, Allied Health Care And Nursing); Navis, Gerjan J; Zhu, Yinjie

BACKGROUND: Preventing metabolic syndrome (MetS) and frailty in older adults is crucial for healthy aging. The association between MetS and physical frailty is well-documented, with low-grade inflammation as potential explanation. However, the association between MetS and frailty as a multidimensional …

2024-11-13AlgemeenArtikel

Guidance for assessment of the inflammation etiologic criterion for the GLIM diagnosis of malnutrition: A modified Delphi approach

Cederholm, Tommy; Jensen, Gordon; Ballesteros-Pomar, Maria; Blaauw, Renee; Correia, Maria Isabel; Cuerda, Cristina; Evans, David; Fukushima, Ryoji; Ochoa Gautier, Juan; Gonzalez, Maria Cristina; van Gossum, Andre; Gramlich, Leah; Hartono, Josep; Heymsfield, Steven; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Jayatissa, Renuka; Keller, Heather; Malone, Ainsley; Manzanares, William; McMahon, M Molly; Mendez, Yolanda; Mogensen, Kris; Mori, Naoharu; Muscaritoli, Maurizio; Contreras Nogales, Guillermo; Nyulasi, Ibolya; Phillips, Wendy; Pirlich, Matthias; Pisprasert, Veeradej; Rothenberg, Elisabet; de van der Schueren, Marian; Ping Shi, Han; Steiber, Alison; Winkler, Marion; Barazzoni, Rocco; Compher, Charlene

Background & aims: The Global Leadership Initiative on Malnutrition (GLIM) approach to malnutrition diagnosis is based on assessment of three phenotypic (weight loss, low body mass index, and reduced skeletal muscle mass) and two etiologic (reduced food intake/assimilation and disease burden/inflammation) …

2024-05-01AlgemeenArtikel

Guidance for assessment of the inflammation etiologic criterion for the GLIM diagnosis of malnutrition: A modified Delphi approach

Jensen, Gordon; Cederholm, Tommy; Ballesteros-Pomar, Maria; Blaauw, Renee; Correia, Maria Isabel; Cuerda, Cristina; Evans, David; Fukushima, Ryoji; Ochoa Gautier, Juan; Gonzalez, Maria Cristina; van Gossum, Andre; Gramlich, Leah; Hartono, Josep; Heymsfield, Steven; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Jayatissa, Renuka; Keller, Heather; Malone, Ainsley; Manzanares, William; McMahon, M Molly; Mendez, Yolanda; Mogensen, Kris; Mori, Naoharu; Muscaritoli, Maurizio; Contreras Nogales, Guillermo; Nyulasi, Ibolya; Phillips, Wendy; Pirlich, Matthias; Pisprasert, Veeradej; Rothenberg, Elisabet; de van der Schueren, Marian; Ping Shi, Han; Steiber, Alison; Winkler, Marion; Compher, Charlene; Barazzoni, Rocco

Background: The Global Leadership Initiative on Malnutrition (GLIM) approach to malnutrition diagnosis is based on assessment of three phenotypic (weight loss, low body mass index, and reduced skeletal muscle mass) and two etiologic (reduced food intake/assimilation and disease burden/inflammation) criteria, …

2024-01-15AlgemeenArtikel

Sulforaphane as a potential modifier of calorie-induced inflammation

Steenwijk, H.P. van; Vinken, A.; Osch, F. van; Peppelenbos, H. (Lector); Troost, F.J.; Bast, A.; Semen, K.O.; Boer, A. de

Background and aims: Observational data indicate that diets rich in fruits and vegetables have a positive effect on inflammatory status, improve metabolic resilience and may protect against the development of non-communicable diseases. Nevertheless, experimental evidence demonstrating a causal relationship …

2023-11-28Mens & MaatschappijArtikel

Sex differences in the association between dual-energy x-ray absorptiometry-measured body composition and periodontitis

Zhu, Peijun; Li, An; Cai, Qingqing; Chen, Yuntao; Liu, Yang; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Tjakkes, Geerten-Has; Xu, Shulan

Background: A positive association between obesity based on body mass index (BMI) and periodontitis has been reported. Fat tissue-related systemic inflammation acts as the link to periodontal comorbidities of obesity. However, the BMI is unable to distinguish fat and fat-free tissues. More precise measures …

2023-08-28AlgemeenArtikel

Disease-related malnutrition with inflammation and cachexia

Muscaritoli, Maurizio; Imbimbo, Giovanni; Jager-Wittenaar, Harriët (Healthy Ageing, Allied Health Care And Nursing); Cederholm, Tommy; Rothenberg, Elisabet; di Girolamo, Filippo Giorgio; Amabile, Maria Ida; Sealy, Martine (Healthy Ageing, Allied Health Care And Nursing); Schneider, Stéphane; Barazzoni, Rocco; Biolo, Gianni; Molfino, Alessio

In 2010, the definition of cachexia was jointly developed by the European Society for Clinical Nutrition and Metabolism (ESPEN) Special Interest Groups (SIG) "Cachexia-anorexia in chronic wasting diseases" and "Nutrition in geriatrics". Cachexia was considered as a synonym of disease-related malnutrition …

2023-08AlgemeenArtikel

Towards precision medicine for septic patients

Bram Snoek (Student)

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …

2023-07-05Gezondheid; …Bachelor

Obesity-induced TET2 disfunction in DNMT3A mutated haematopoietic cells increases myelopoiesis, resulting in increased risk for cardiovascular disease development

Arina Kochetkova (Student)

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

2023-06-13Gezondheid; …Bachelor

Effects of Exercise during Chemo- or Radiotherapy on Immune Markers

Anne de Hoop (Onderzoeker); Karin Valkenet (Onderzoeker); Jaap Dronkers (Onderzoeker); Cyrille Krul (Lector); Jelle Ruurda (Onderzoeker); Cindy Veenhof (Lector); Raymond Pieters (Lector)

Introduction: Patients with cancer receiving radio- or chemotherapy undergo many immunological stressors. Chronic regular exercise has been shown to positively influence the immune system in several populations, while exercise overload may have negative effects. Exercise is currently recommended for …

2023GezondheidArtikel

Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach

Jonas van Ertvelde (Onderzoeker); Anouk Verhoeven (Onderzoeker); Amy Maerten (Onderzoeker); Axelle Cooreman (Onderzoeker); Bruna dos Santos Rodrigues (Onderzoeker); Julen Sanz-Serrano (Onderzoeker); Milos Mihajlovic (Onderzoeker); Ignacio Tripodi (Onderzoeker); Marc Teunis (Onderzoeker); Ramiro Jover (Onderzoeker); Thomas Luechtefeld (Onderzoeker); Tamara Vanhaecke (Onderzoeker); Jian Jang (Onderzoeker); Mathieu Vinken (Onderzoeker)

Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected …

2023GezondheidArtikel

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