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The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands

Sealy, Martine J (Healthy Ageing, Allied Health Care And Nursing); van Vliet, Iris M Y (Healthy Ageing, Allied Health Care And Nursing); Jager-Wittenaar, Harriët (Healthy Ageing, Allied Health Care And Nursing); Navis, Gerjan J; Zhu, Yinjie

BACKGROUND: Preventing metabolic syndrome (MetS) and frailty in older adults is crucial for healthy aging. The association between MetS and physical frailty is well-documented, with low-grade inflammation as potential explanation. However, the association between MetS and frailty as a multidimensional …

2024-11-13AlgemeenArtikel

Sulforaphane as a potential modifier of calorie-induced inflammation

Steenwijk, H.P. van; Vinken, A.; Osch, F. van; Peppelenbos, H. (Lector); Troost, F.J.; Bast, A.; Semen, K.O.; Boer, A. de

Background and aims: Observational data indicate that diets rich in fruits and vegetables have a positive effect on inflammatory status, improve metabolic resilience and may protect against the development of non-communicable diseases. Nevertheless, experimental evidence demonstrating a causal relationship …

2023-11-28Mens & MaatschappijArtikel

Obesity-induced TET2 disfunction in DNMT3A mutated haematopoietic cells increases myelopoiesis, resulting in increased risk for cardiovascular disease development

Arina Kochetkova (Student)

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

2023-06-13Gezondheid; …Bachelor

The effect of a multidisciplinary lifestyle program for patients with rheumatoid arthritis, an increased risk for rheumatoid arthritis or with metabolic syndrome-associated osteoarthritis

Walrabenstein, Wendy; van der Leeden, Marike; Weijs, Peter (Lectoraat Voeding En Beweging); van Middendorp, Henriët; Wagenaar, Carlijn; van Dongen, Johanna Maria; Nieuwdorp, Max; de Jonge, Catharina Sophia; van Boheemen, Laurette; van Schaardenburg, Dirkjan

Low-grade inflammation and metabolic syndrome are seen in many chronic diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). Lifestyle interventions which combine different non-pharmacological therapies have shown synergizing effects in improving outcomes in patients with other chronic …

2021-10-18AlgemeenArtikel

Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study

Liberman, Keliane; Njemini, Rose; Luiking, Yvette; Forti, Louis N.; Verlaan, Sjors; Bauer, Jürgen M.; Memelink, Robert; Brandt, Kirsten; Donini, Lorenzo; Maggio, Marcello; Mets, Tony; Weijers, Sander L.J.; Sieber, Cornel; Cederholm, Tommy; Bautmans, Ivan

Background: A chronic low-grade infammatory profle (CLIP) is associated with sarcopenia in older adults. Protein and Vitamin (Vit)D have immune-modulatory potential, but evidence for efects of nutritional supplementation on CLIP is limited. Aim To investigate whether 13 weeks of nutritional supplementation …

2019-06AlgemeenArtikel

Attenuated strength gains during prolonged resistance exercise training in older adults with high inflammatory status

Hangelbroek, Roland W.J.; Knuiman, Pim; Tieland, Michael (Lectoraat Voeding En Beweging); de Groot, Lisette C.P.G.M.

Objectives Chronic systemic low grade inflammation is associated with the age-related loss of muscle mass. Resistance exercise has been suggested to reduce or lower chronic systemic low grade inflammation. However, systemic chronic low-grade inflammation may adversely affect the adaptive response to …

2018-06AlgemeenArtikel

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