Alzheimer's disease (AD) is the common neurodegenerative disorder and the most frequent cause of dementia. The disease accounts around 80% of all dementia diagnoses. The main reason of developing AD is amyloid cascade which starts from missense mutations in APP (amyloid precursor protein), Rho-associated …

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

5% to 10% of all cancers are linked to gene mutations inherited from parents. The most common gene related to hereditary cancer is the p53 gene. It is a crucial tumor suppressor. However, the mutated gene is commonly inherited from one generation to another one. The functions of p53 resume to the activation …

SMPD4 is a neutral sphingomyelinase that plays an important role in sphingolipid metabolism. Sphingolipids are a family of lipid molecules abundantly present in the brain where they play an important role in the brain development and function due to their essential cellular role as structural components …

From the thesis: "Summary Metabolic diseases that are characterized by a disturbance in energy balance because of feeding behavior, such as obesity and anorexia are known to be a world-wide problem. A better understanding in central regulation of energy intake and metabolism could give more insight in …

Recent studies showed that in teb mutants (teb2 & teb5 (mutant allele 2 and 5 of the Teb gene)) no T-DNA integration was detectable, meaning that if there still is any T-DNA integration it will be in very low frequencies (Kregten et al., 2016). This suggests that the Teb gene is essentially involved …

Heme is a suggested limiting factor in peroxidase production by Aspergillus spp., which are well-known suitable hosts for heterologous protein production. In this study, the role of genes coding for coproporphyrinogen III oxidase (hemF) and ferrochelatase (hemH) was analyzed by means of deletion and …

To increase knowledge on haem biosynthesis in filamentous fungi like Aspergillus niger, pathway-specific gene expression in response to haem and haem intermediates was analysed. This analysis showed that iron, 5-aminolevulinic acid (ALA) and possibly haem control haem biosynthesis mostly via modulating …