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Sex differences in the association between dual-energy x-ray absorptiometry-measured body composition and periodontitis

Zhu, Peijun; Li, An; Cai, Qingqing; Chen, Yuntao; Liu, Yang; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Tjakkes, Geerten-Has; Xu, Shulan

Background: A positive association between obesity based on body mass index (BMI) and periodontitis has been reported. Fat tissue-related systemic inflammation acts as the link to periodontal comorbidities of obesity. However, the BMI is unable to distinguish fat and fat-free tissues. More precise measures …

2023-08-28AlgemeenArtikel

Disease-related malnutrition with inflammation and cachexia

Muscaritoli, Maurizio; Imbimbo, Giovanni; Jager-Wittenaar, Harriët (Healthy Ageing, Allied Health Care And Nursing); Cederholm, Tommy; Rothenberg, Elisabet; di Girolamo, Filippo Giorgio; Amabile, Maria Ida; Sealy, Martine (Healthy Ageing, Allied Health Care And Nursing); Schneider, Stéphane; Barazzoni, Rocco; Biolo, Gianni; Molfino, Alessio

In 2010, the definition of cachexia was jointly developed by the European Society for Clinical Nutrition and Metabolism (ESPEN) Special Interest Groups (SIG) "Cachexia-anorexia in chronic wasting diseases" and "Nutrition in geriatrics". Cachexia was considered as a synonym of disease-related malnutrition …

2023-08AlgemeenArtikel

Obesity-induced TET2 disfunction in DNMT3A mutated haematopoietic cells increases myelopoiesis, resulting in increased risk for cardiovascular disease development

Arina Kochetkova (Student)

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

2023-06-13Gezondheid; …Bachelor

Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

B. den Hollander; A.R.J. Veenvliet; Marieke Lindenschot; P. van Essen; G. Peters; A. Santos-Gómez; M. Olivella; X. Altafaj; M.M. Brands; B.A.W. Jacobs; C.D. van Karnebeek

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

2023AlgemeenArtikel

The effect of SMPD4 absence on mitosis and neuronal progenitor cell number

Marta Sério Ferreira (Student); Kas Wannee (Docent); José de Winter (Docent); Daphne Smits (Begeleider)

SMPD4 is a neutral sphingomyelinase that plays an important role in sphingolipid metabolism. Sphingolipids are a family of lipid molecules abundantly present in the brain where they play an important role in the brain development and function due to their essential cellular role as structural components …

2021-06-21Natuur & LandbouwBachelor

Construct validity of the OCTOPuS stratification algorithm for allocating patients with knee osteoarthritis into subgroups.

J. Knoop; R.W.J.G. Ostelo; M. van der Esch; A. de Zwart; K.L. Bennell; M van der Leeden; J Dekker

BACKGROUND: We recently developed a model of stratified exercise therapy, consisting of (i) a stratification algorithm allocating patients with knee osteoarthritis (OA) into one of the three subgroups ('high muscle strength subgroup' representing a post-traumatic phenotype, 'low muscle strength subgroup' …

2021AlgemeenArtikel

Construct validity of the OCTOPuS stratification algorithm for allocating patients with knee osteoarthritis into subgroups

Knoop, Jesper; Ostelo, Raymond W. J. G.; van der Esch, Martin (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen); de Zwart, Arjan; Bennell, Kim L.; van der Leeden, Marike; Dekker, Joost

2021AlgemeenArtikel

A consensus-based framework for conducting and reporting osteoarthritis phenotype research

van Spil, W. E.; Bierma-Zeinstra, S. M. A.; Deveza, L. A.; Arden, N. K.; Bay-Jensen, A.-C.; Kraus, V. Byers; Carlesso, L.; Christensen, R.; Van Der Esch, M. (Centre Of Expertise Urban Vitality); Kent, P.; Knoop, J.; Ladel, C.; Little, C. B.; Loeser, R. F.; Losina, E.; Mills, K.; Mobasheri, A.; Nelson, A. E.; Neogi, T.; Peat, G. M.; Rat, A.-C.; Steultjens, M.; Thomas, M. J.; Valdes, A. M.; Hunter, D. J.

BACKGROUND: The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemingly plausible, …

2020-03-20AlgemeenArtikel

A consensus-based framework for conducting and reporting osteoarthritis phenotype research.

W.E. van Spil; S.M.A. Bierma-Zeinstra; L.A. Deveza; N.K. Arden; A.C. Bay-Jensen; V.B. Kraus; L. Carlesso; R. Christensen; M. van der Esch; P. Kent; J. Knoop; C. Ladel; C.B. Little; R.F. Loeser; E. Losina; K. Mills; A. Mobasheri; A.E. Nelson; T. Neogi; G.M. Peat; A.C. Rat; M. Steultjens; M.J. Thomas; A.M. Valdes; D.J. Hunter

2020AlgemeenArtikel

Can the combined use of two screening instruments improve the predictive power of dependency in (instrumental) activities of daily living, mortality and hospitalization in old age?

Linda Op het Veld (Lid Lectoraat); E. van Rossum (Lector); G.I.J.M. Kempen; Sandra Beurskens (Lector); K.J. Hajema; Henrica C.W. de Vet

Background: Due to differences in the definition of frailty, many different screening instruments have been developed. However, the predictive validity of these instruments among community-dwelling older people remains uncertain. Objective: To investigate whether combined (i.e. sequential or parallel) …

2019-06-12GezondheidArtikel

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