HBO Kennisbank

Sex differences in the association between dual-energy x-ray absorptiometry-measured body composition and periodontitis

Zhu, Peijun; Li, An; Cai, Qingqing; Chen, Yuntao; Liu, Yang; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Tjakkes, Geerten-Has; Xu, Shulan

Background: A positive association between obesity based on body mass index (BMI) and periodontitis has been reported. Fat tissue-related systemic inflammation acts as the link to periodontal comorbidities of obesity. However, the BMI is unable to distinguish fat and fat-free tissues. More precise measures …

2023-08-28AlgemeenArtikel

Immune monitoring of T cell and NK cell subsets of non-small cell lung cancer patients receiving neoadjuvant treatment with Chemoradiotherapy, Nivolumab, and Ipilimumab

HL Prijs 2022

Non-small cell lung cancer (NSCLC) occurs in approximately 80-85% of all lung cancer patients and has a 5-year overall survival (OS) of only 15-20%. In this study, 29 NSCLC patients received neoadjuvant treatment with Chemoradiotherapy, Nivolumab, and Ipilimumab. This study aimed to investigate the effects …

2022-06-14GezondheidBachelor

Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients

Alkema, Wynand (Data Science For Life Science & Health); He, Xuehui; Kaffa, Charlotte; Joosten, Irma; Smeets, Ruben L; Koenen, Hans J P M; Mulder, Michelle L.M.; van den Reek, Juul M.P.A.; Urbano, Paulo C.M.; Wang, Xinhui; van Cranenbroek, Bram; van Rijssen, Esther; Van Den Hoogen, Frank H.J.; de Jong, Elke M. G .J.; Wenink, Mark H.

Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment but difficult for dermatologists to implement. We, therefore, aimed …

2021-10-12AlgemeenArtikel

Presence or Absence of Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease is Associated With Distinct Phenotypes

C.L. Cruthirds; Barbara van der Meij; A. Wierzchowska-McNew; N.E.P. Deutz; M.P.K.J. Engelen

2021AlgemeenArtikel

The Dutch direct-to-consumer genetic test market can benefit from specific regulations regarding informed consent

Achtergrond: Direct-to-consumer genetische testen (DTC-GT) zijn genetische zelftesten die worden aangeboden via het internet. Ze gebruiken varianten in DNA om een uitspraak te doen over een fenotype, een eigenschap of aandoening. Nederland heeft geen specifieke regulatie voor deze testen. Het gevaar …

2021GezondheidBachelor

Construct validity of the OCTOPuS stratification algorithm for allocating patients with knee osteoarthritis into subgroups

Knoop, Jesper; Ostelo, Raymond W. J. G.; van der Esch, Martin (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen); de Zwart, Arjan; Bennell, Kim L.; van der Leeden, Marike; Dekker, Joost

BACKGROUND: We recently developed a model of stratified exercise therapy, consisting of (i) a stratification algorithm allocating patients with knee osteoarthritis (OA) into one of the three subgroups ('high muscle strength subgroup' representing a post-traumatic phenotype, 'low muscle strength subgroup' …

2021AlgemeenArtikel

Construct validity of the OCTOPuS stratification algorithm for allocating patients with knee osteoarthritis into subgroups.

J. Knoop; R.W.J.G. Ostelo; M. van der Esch; A. de Zwart; K.L. Bennell; M van der Leeden; J Dekker

BACKGROUND: We recently developed a model of stratified exercise therapy, consisting of (i) a stratification algorithm allocating patients with knee osteoarthritis (OA) into one of the three subgroups ('high muscle strength subgroup' representing a post-traumatic phenotype, 'low muscle strength subgroup' …

2021AlgemeenArtikel

A consensus-based framework for conducting and reporting osteoarthritis phenotype research

van Spil, W. E.; Bierma-Zeinstra, S. M. A.; Deveza, L. A.; Arden, N. K.; Bay-Jensen, A.-C.; Kraus, V. Byers; Carlesso, L.; Christensen, R.; Van Der Esch, M. (Centre Of Expertise Urban Vitality); Kent, P.; Knoop, J.; Ladel, C.; Little, C. B.; Loeser, R. F.; Losina, E.; Mills, K.; Mobasheri, A.; Nelson, A. E.; Neogi, T.; Peat, G. M.; Rat, A.-C.; Steultjens, M.; Thomas, M. J.; Valdes, A. M.; Hunter, D. J.

BACKGROUND: The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemingly plausible, …

2020-03-20AlgemeenArtikel

A consensus-based framework for conducting and reporting osteoarthritis phenotype research.

W.E. van Spil; S.M.A. Bierma-Zeinstra; L.A. Deveza; N.K. Arden; A.C. Bay-Jensen; V.B. Kraus; L. Carlesso; R. Christensen; M. van der Esch; P. Kent; J. Knoop; C. Ladel; C.B. Little; R.F. Loeser; E. Losina; K. Mills; A. Mobasheri; A.E. Nelson; T. Neogi; G.M. Peat; A.C. Rat; M. Steultjens; M.J. Thomas; A.M. Valdes; D.J. Hunter

BACKGROUND: The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to clinical management. Although seemingly plausible, …

2020AlgemeenArtikel

ADHD and the power of generalization

te Meerman, Sanne; Freedman, Justin; Batstra, Laura; Grietens, Hans; Hoekstra, Rink; Batstra, Laura; Grietens, Hans

ADHD en reïficatie Dit proefschrift begint met een quote van de 11-jarige Sylvia, die denkt: “ADHD is net als kanker (…) maar je gaat er niet dood aan”. ADHD is zeker geen ziekte als kanker, maar een concept uit de Diagnostic and Statistical Manual (DSM), waarvan momenteel de 5e editie uit is. De DSM-5 …

2019-06-20AlgemeenProefschrift

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