Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected …

Presenting techniques, case-studies and methodologies that combine the use of simulation approaches with optimization techniques for facing problems in manufacturing, logistics, or aeronautical problems, this book provides solutions to common industrial problems in several fields, which range from manufacturing …

The airline industry is one of the most affected by operational disruptions, defined as deviations from originally planned operations. Due to airlines network configuration, delays are rapidly propagated to connecting flights, substantially increasing unexpected costs for the airlines.

The aviation industry is expected to grow at a pace of 4 % per annum in the coming years, therefore it is necessary to have techniques that support the management of the resources at hand in the best possible way so that facility expansion is delayed as much as possible with the corresponding capital …