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Obesity-induced TET2 disfunction in DNMT3A mutated haematopoietic cells increases myelopoiesis, resulting in increased risk for cardiovascular disease development

Arina Kochetkova (Student)

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

2023-06-13Gezondheid; …Bachelor

Horizontal gene transfer of an IncP1 plasmid to soil bacterial community introduced by Escherichia coli through manure amendment in soil microcosms

Macedo, G.; Olesen, A.K.; Maccario, L.; Hernandez Leal, L.; Maas, P.M.F. van der (Lector); Heederik, D.; Mevius, D.; Sørensen, S.J.; Schmitt, H.

The quantification and identification of new plasmid-acquiring bacteria in representative mating conditions is critical to characterize the risk of horizontal gene transfer in the environment. This study aimed to quantify conjugation events resulting from manure application to soils and identify the …

2022-07-27Natuur & LandbouwArtikel

Immune monitoring of T cell and NK cell subsets of non-small cell lung cancer patients receiving neoadjuvant treatment with Chemoradiotherapy, Nivolumab, and Ipilimumab

HL Prijs 2022

Non-small cell lung cancer (NSCLC) occurs in approximately 80-85% of all lung cancer patients and has a 5-year overall survival (OS) of only 15-20%. In this study, 29 NSCLC patients received neoadjuvant treatment with Chemoradiotherapy, Nivolumab, and Ipilimumab. This study aimed to investigate the effects …

2022-06-14GezondheidBachelor

Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients

Alkema, Wynand (Data Science For Life Science & Health); He, Xuehui; Kaffa, Charlotte; Joosten, Irma; Smeets, Ruben L; Koenen, Hans J P M; Mulder, Michelle L.M.; van den Reek, Juul M.P.A.; Urbano, Paulo C.M.; Wang, Xinhui; van Cranenbroek, Bram; van Rijssen, Esther; Van Den Hoogen, Frank H.J.; de Jong, Elke M. G .J.; Wenink, Mark H.

Psoriasis (Pso) is a chronic inflammatory skin disease, and up to 30% of Pso patients develop psoriatic arthritis (PsA), which can lead to irreversible joint damage. Early detection of PsA in Pso patients is crucial for timely treatment but difficult for dermatologists to implement. We, therefore, aimed …

2021-10-12AlgemeenArtikel

DiAgRaMs: Selecting biomarkers for gut-permeability

Smelt, Maaike; Faber, Folkert (Biobased Ingredients And Materials); Binnema, Doede J.; Leistra, Nynke; Sanders, Ilson; Ebbinge, Arianne; de Jong, Rosalie; Hiemstra, Stan; van der Veen, Mariska; Kloosterman, Rianne; Wekema, Lieske

2019-12-17AlgemeenConferentiebijdrage

Diagrams

Faber, Folkert

Tijdens het eindsymposium van Diagrams werden de resultaten vanuit Hanzehogeschool gepresenteerd.

2018-02-01GezondheidConferentiebijdrage

Phase II of the DiAgRaMs project

Smelt, Maaike

2018-01-18GezondheidConferentiebijdrage

Glycation of the Major Milk Allergen β-Lactoglobulin Changes Its Allergenicity by Alterations in Cellular Uptake and Degradation

Marija Perusko (Onderzoeker); Manon van Roest (Onderzoeker); Dragana Stanic-Vucinic (Onderzoeker); Peter J. Simons (Onderzoeker); Raymond Pieters (Lector); Tanja Cirkovic-Velickovic (Onderzoeker); Joost Smit (Onderzoeker)

From the article: "Scope: During food processing, the Maillard reaction ( М R) may occur, resulting in the formation of glycated proteins. Glycated proteins are of particular importance in food allergies because glycation may influence interactions with the immune system. This study compared native …

2018GezondheidArtikel

DiAgRaMs: selecting biomarkers for gut-permeability

Smelt, Maaike

Increased intestinal permeability is linked to both intestinal as well as peripheral inflammatory disease. Contact between intestinal contents and the underlying immune system may account for excessive immune activation and local as well as systemic inflammation. Decreasing intestinal permeability using …

2017-12-19AlgemeenConferentiebijdrage

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

Marlotte M. Vonk (Onderzoeker); Laura Wagenaar (Onderzoeker); Raymond Pieters (Lector); Léon M.J. Knippels (Onderzoeker); L.E.M. Willemsen (Onderzoeker); J.J. Smit (Onderzoeker); BCAM van Esch (Onderzoeker); J. Garssen (Onderzoeker)

From Pubmed: " BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in …

2017GezondheidArtikel

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