Background In adolescents with non-pathological and pathological joint hypermobility, gait deviations have been associated with pain and fatigue. It remains unclear what distinguishes the non-pathological form of joint hypermobility (JH) from pathological forms (i.e. hypermobile Ehlers-Danlos syndrome …

Objective Major issues in children with Marfan syndrome (MFS) are pain, fatigue and joint hypermobility which might influence functional ability. We recently studied these aspects in children with Ehlers-Danlos syndrome hypermobility type (EDS-HT) and hypermobility spectrum disorders (HSD). What can …

The objective of this chapter is to provide clinicians with a clinical model of hEDS and HSD for which treatment can be optimized to the needs of the individual patient. Due to the complexity of the symptom profiles of HSD/hEDS, the international classification of functioning (ICF) will be adopted as …