HBO Kennisbank

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Incidence of Air Leaks in Critically Ill Patients with Acute Hypoxemic Respiratory Failure Due to COVID-19

Goossen, Robin L.; Verboom, Mariëlle; Blacha, Mariëlle; Smesseim, Illaa; Beenen, Ludo F. M.; van Meenen, David M. P.; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

Subcutaneous emphysema, pneumothorax and pneumomediastinum are well-known complications of invasive ventilation in patients with acute hypoxemic respiratory failure. We determined the incidences of air leaks that were visible on available chest images in a cohort of critically ill patients with acute …

2023-03AlgemeenArtikel

A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment

Paul G. Werthmann (Onderzoeker); Lothar Kindermann (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Background Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating …

2018-04-09GezondheidArtikel

The impact of protein quantity during energy restriction on genome-wide gene expression in adipose tissue of obese humans

Van Bussel, I P G; Backx, E M P; De Groot, C P G M; Tieland, M (Lectoraat Voeding En Beweging); Müller, M; Afman, L A

BACKGROUND: Overweight and obesity is a growing health problem worldwide. The most effective strategy to reduce weight is energy restriction (ER). ER has been shown to be beneficial in disease prevention and it reduces chronic inflammation. Recent studies suggest that reducing the protein quantity of …

2017-07AlgemeenArtikel

Immune-related and adverse drug reactions to low versus high initial doses of Viscum album L. in cancer patients

Friedemann Schad (Onderzoeker); Anja Thronicke (Onderzoeker); Antje Merkle (Onderzoeker); Harald Matthes (Onderzoeker); Megan L. Steele (Onderzoeker)

Background: Immune-related adverse drug reactions (ADRs) to immunotherapy agents have been associated with beneficial clinical outcomes in oncology. Viscum album L. (VA, European mistletoe) is frequently used as an immunomodulatory agent alongside conventional cancer treatment in Europe. VA has been …

2017GezondheidArtikel

The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

Marlotte M. Vonk (Onderzoeker); Laura Wagenaar (Onderzoeker); Raymond Pieters (Lector); Léon M.J. Knippels (Onderzoeker); L.E.M. Willemsen (Onderzoeker); J.J. Smit (Onderzoeker); BCAM van Esch (Onderzoeker); J. Garssen (Onderzoeker)

From Pubmed: " BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in …

2017GezondheidArtikel

Wat is het effect van obesitas op de celgrootte en collageenvorming in gonadaal, subcutaan en visceraal vetweefsel? =

Mark Boer (Student)

Obesitas is een steeds vaker voorkomende aandoening in West-Europa, Noord-Amerika en andere welvarende delen van de wereld. Uit recent onderzoek van het RIVM is gebleken dat van de gehele volwassen populatie in Nederland in 2012, zo’n 40% overgewicht heeft en 12% obesitas. Bij obesitas vindt een ophoping …

2014-06-27AlgemeenBachelor

Design of the SHAPE-2 study: the effect of physical activity, in addition to weight loss, on biomarkers of postmenopausal breast cancer risk

Willemijn A.M. van Gemert; Tim Takken; Anne M. May; Harriët Wittink (Lector); Albertine J. Schuit; Job van der Palen; Petra H.M. Peeters; Evelyn M. Monninkhof; Wouter B. Veldhuis; Jolijn I. Iestra

Background: Physical inactivity and overweight are two known risk factors for postmenopausal breast cancer. Former exercise intervention studies showed that physical activity influences sex hormone levels, known to be related to postmenopausal breast cancer, mainly when concordant loss of body weight …

2013GezondheidArtikel

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