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Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach

Jonas van Ertvelde (Onderzoeker); Anouk Verhoeven (Onderzoeker); Amy Maerten (Onderzoeker); Axelle Cooreman (Onderzoeker); Bruna dos Santos Rodrigues (Onderzoeker); Julen Sanz-Serrano (Onderzoeker); Milos Mihajlovic (Onderzoeker); Ignacio Tripodi (Onderzoeker); Marc Teunis (Onderzoeker); Ramiro Jover (Onderzoeker); Thomas Luechtefeld (Onderzoeker); Tamara Vanhaecke (Onderzoeker); Jian Jang (Onderzoeker); Mathieu Vinken (Onderzoeker)

Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected …

2023GezondheidArtikel

In vitro–in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans

Shi, M.; Dong, Y.; Bouwmeester, H.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R- …

2022-05-23GezondheidArtikel

New approach methodologies (NAMs) for human-relevant biokinetics predictions

Punt, A.; Bouwmeester, H.; Blaauboer, B.J.; Strikwold, M. (Lector)

For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck. To enhance the field, a team …

2020-06-08GezondheidArtikel

Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone

Shi, M.; Bouwmeester, H.; Rietjens, I.M.C.M.; Strikwold, M. (Associate Lector)

Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data …

2020-05-04GezondheidArtikel

Integrating physiologically based kinetic (PBK) and Monte Carlo modelling to predict inter-individual and inter-ethnic variation in bioactivation and liver toxicity of lasiocarpine

Ning, J.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

The aim of the present study was to predict the effect of inter-individual and inter-ethnic human kinetic variation on the sensitivity towards acute liver toxicity of lasiocarpine in the Chinese and the Caucasian population, and to derive chemical specific adjustment factors (CSAFs) by integrating variation …

2019-09-11GezondheidArtikel

Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine

Ning, J.; Chen, L.; Strikwold, M. (Lector)

Lasiocarpine and riddelliine are pyrrolizidine alkaloids (PAs) known to cause liver toxicity. The aim of this study was to predict the inter-species and inter-ethnic human differences in acute liver toxicity of lasiocarpine and riddelliine using physiologically based kinetic (PBK) modelling based reverse …

2019-01-19GezondheidArtikel

Selecting the dose metric in reverse dosimetry based QIVIVE

Rietjens, I.M.C.M.; Ning, J.; Chen, L.; Wesseling, S.; Strikwold, M. (Lector); Louisse, J.

Reply to ‘Comment on ‘Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human diferences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine’ by Ning et al., Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02397-7’, Arch Toxicol doi: …

2019GezondheidArtikel

Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds

Peter I. Racza (Onderzoeker); Marjolein Wildwater (Onderzoeker); Martijn Rooseboom (Onderzoeker); Engelien Kerkhof (Onderzoeker); Raymond Pieters (Lector); Elena Santidrian Yebra-Pimentela (Onderzoeker); Ron P. Dirks (Onderzoeker); Herman P. Spaink (Onderzoeker); Chantal Smulders (Onderzoeker); Graham F. Whale (Onderzoeker)

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have …

2017-06-27GezondheidArtikel

Human lung epithelial cell cultures for analysis of inhaled toxicants

P.S. Hiemstra (Onderzoeker); G. Grootaers (Onderzoeker); A.M. van der Does (Onderzoeker); Cyrille Krul (Lector); Ingeborg M. Kooter

doi: 10.1016/j.tiv.2017.11.005 / PMID:29155131

2017GezondheidArtikel

Intra- and inter-laboratory validation of an innovative huFcεRIα-RBL-2H3 degranulation assay for in vitro allergenicity assessment of whey hydrolysates

Marjan Gros; Linda Cox; Johan Garssen; Niels de Jong; Diana Kegler; Reiko Teshima; Peter J. Simons; Laura Kruijssen; Manon van Roest; Raymond Pieters (Lector); Léon M.J. Knippels; Marieke Smits (Lid Lectoraat); Marc Teunis (Lid Lectoraat); Karen Knipping; Louis Boon

from the article: "Cow's milk-derived whey hydrolysates are milk substitutes for cow's milk allergic infants. Safety assessment of these hydrolysates is crucial. Currently, huFcεRIα-RBL-2H3 cells, sensitized with serum IgE from cow's milk allergic patients, are used to assess in vitro residual allergenicity. …

2016-02-24Natuur & LandbouwArtikel

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