In this research, acrylate crosslinked PEG-b-PS polymersomes were synthesized and extensively tested. Polymersomes are nanovesicles that are self-assembled from amphiphilic block copolymers. Like liposomes, they can contain aqueous solutions in the core, which makes them interesting in the field of nanomedicine. …

Abstract Aureobasidium is omnipresent and can be isolated from air, water bodies, soil, wood, and other plant materials, as well as inorganic materials such as rocks and marble. A total of 32 species of this fungal genus have been identified at the level of DNA, of which Aureobasidium pullulans is best …

Overusing non-degradable plastics causes a series of environmental issues, inferring a switch to biodegradable plastics. Polyhydroxyalkanoates (PHAs) are promising biodegradable plastics that can be produced by many microbes using various substrates from waste feedstock. However, the cost of PHAs production …

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R- …

The purpose of this research is to validate and optimize the synthesis of the natively linked α-UbADPr & β-UbADPr (19α,β) on arginine 42 to further study in the enzymes of Legionella Pneumophilia. In the synthesis of UbADPr the sub goal was to synthesize as much as possible of two molecules (building …

Plastic pollution has increased over the years and this affects especially seabirds which are vulnerable to this type of pollution. A species that is used as indicator species for plastic pollution is the short-tailed shearwater (Ardenna tenuirostris). These seabirds belong to the procellariids group …

Due to the depletion of fossil fuel resources and concern about increasing atmospheric CO2 levels, the production of microbial oil as source for energy and chemicals is considered as a sustainable alternative. A promising candidate strain for the production of microbial oil is the oleaginous yeast Schwanniomyces …

Background: Pseudomonas aeruginosa is a nosocomial pathogen that causes severe infections in immunocompromised patients. Biofilm plays a significant role in the resistance of this bacterium and complicates the treatment of its infections. In this study, the effect of lyticase and β-glucosidase enzymes …

From TU Delft repository: "Intestinal transporter proteins and metabolizing enzymes play a crucial role in the oral absorption of a wide variety of drugs. The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and …

Biofilm is an important virulence factor in Pseudomonas aeruginosa and has a substantial role in antibiotic resistance and chronic burn wound infections. New therapeutic agents against P. aeruginosa, degrading biofilms in burn wounds and improving the efficacy of current antimicrobial agents, are required. …