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Zocht je misschien: restoration?

Oyster larvae used for ecosystem restoration benefit from increased thermal fluctuation

Katharina Alter (Onderzoeker); Pascalle Jacobs (Onderzoeker); Annalisa Delre (Onderzoeker); Bianka Rasch (Onderzoeker); Catharina Philippart (Onderzoeker); Myron Peck (Onderzoeker)

A bottleneck in restoring self-sustaining beds of the European oyster (Ostrea edulis) is the successful development and settlement of larvae to bottom habitats. These processes are largely governed by temperature but a mechanistic understanding of larval performance across ecologically relevant temperatures …

2023-12-02Natuur & LandbouwArtikel

Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Nollet, Edgar E; Duursma, Inez; Rozenbaum, Anastasiya; Eggelbusch, Moritz; Wüst, Rob C I; Schoonvelde, Stephan A C; Michels, Michelle; Jansen, Mark; van der Wel, Nicole N; Bedi, Kenneth C Jr; Margulies, Kenneth B; Nirschl, Jeff; Kuster, Diederik W D; van der Velden, Jolanda

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

2023-04-01AlgemeenArtikel

Profiling acidic metabolites by capillary electrophoresis-mass spectrometry in low numbers of mammalian cells using a novel chemical derivatization approach

Marlien van Mever (Onderzoeker); Cornelius Willacey (Onderzoeker); Wei Zhang (Onderzoeker); Nicolas Drouin (Onderzoeker); Alphert Christina (Onderzoeker); Peter Lindenburg (Lector); Jaco van Veldhoven (Onderzoeker); Daan van der Es (Onderzoeker); Amy Harms (Onderzoeker); Thomas Hankemeier (Onderzoeker); Rawi Ramautar (Onderzoeker)

The simultaneous analysis of a broad range of polar ionogenic metabolites using capillary electrophoresis-mass spectrometry (CE-MS) can be challenging, as two different analytical methods are often required, that is, one for cations and one for anions. Even though CE-MS has shown to be an effective method …

2021-12-14GezondheidArtikel

Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS

PRoVENT-COVID Study Group

Background: Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. Methods: Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is …

2021-12-01AlgemeenArtikel

Mortality associated with early changes in ARDS severity in COVID-19 patients

PRoVENT-COVID

PURPOSE: We investigated changes in ARDS severity and associations with outcome in COVID-19 ARDS patients. METHODS: We compared outcomes in patients with ARDS classified as 'mild', 'moderate' or 'severe' at calendar day 1, and after reclassification at calendar day 2. The primary endpoint was 28-day …

2021-10AlgemeenArtikel

Association of intensity of ventilation with 28-day mortality in COVID-19 patients with acute respiratory failure

PRoVENT-COVID

BACKGROUND: The intensity of ventilation, reflected by driving pressure (ΔP) and mechanical power (MP), has an association with outcome in invasively ventilated patients with or without acute respiratory distress syndrome (ARDS). It is uncertain if a similar association exists in coronavirus disease …

2021-08-06AlgemeenArtikel

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

HOT-ICU Investigators

Abstract Background Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targ...

2021-04-08AlgemeenArtikel

Influence of respiration frequency on heart rate variability parameters:

Soer, R. (Remko) (Associatelector); Six Dijkstra, W.M.C. (Marianne) (Researcher); Bieleman, H,J. (Andre) (Associatelector); Oosterveld, F.G.J. (Frits) (Lector); Rijken, N.H.M. (Noortje) (Phd)

BACKGROUND:Many patients visiting physiotherapists for musculoskeletal disorders face psychosocial challenges which may form a large barrier to recover. There are only a limited number of evidence based psychosocial therapies, but they are mainly based on breathing exercises. OBJECTIVE: to study which …

2021-04-01AlgemeenArtikel

Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID)

PRoVENT-COVID

BACKGROUND: Little is known about the practice of ventilation management in patients with COVID-19. We aimed to describe the practice of ventilation management and to establish outcomes in invasively ventilated patients with COVID-19 in a single country during the first month of the outbreak. METHODS: …

2021-02-01AlgemeenArtikel

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients

DecubICUs Study Team

PURPOSE: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU …

2020-10AlgemeenArtikel

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