Ubiquitin (Ub) is a protein which post-translationally modifies other proteins (its target substrates) and determines their cellular fate. Ub can label substrates for degradation, it can also alter the location of their substrates within a cell or even affect their activity. Chains can be formed via …

Volgens recente nieuwsberichten en uit eigen ervaring lijkt een toenemend aantal jongvolwassenen last te hebben van stress met overspanningsverschijnselen als gevolg. Dit document gaat dieper in op dit onderwerp en onderzoekt de omvang van deze situatie. Om dit probleem tegen te gaan is het noodzakelijk …

Plastic pollution has increased over the years and this affects especially seabirds which are vulnerable to this type of pollution. A species that is used as indicator species for plastic pollution is the short-tailed shearwater (Ardenna tenuirostris). These seabirds belong to the procellariids group …

School health promotion is advocated. Implementation studies on school health promotion are less often conducted as effectiveness studies and are mainly conducted conventionally by assessing fidelity of “one size fits all” interventions. However, interventions that allow for local adaptation are more …

Background: Patient Reported Experience Measures are promoted to be used as an integrated measurement approach in which outcomes are used to improve individual care (micro level), organisational quality (meso level) and external justification (macro level). However, a deeper understanding of implementation …

Granite G682 is a yellow to pink color stone of the Precambrian period, the most famous yellow granite from China. I am from G682 granite town. I used to live in a village surrounded by stones. however, I never knew the beautiful and scary story behind it until I saw hundreds of abandoned quarries in …

Installatierede van Maarten van Gils, lector Smart Business

The concept of deterrence has dominated Western strategic thought for some seven decades. It shows no signs of easing its grip. In the face of any new security threat, such as terrorism or cyber-attacks, one of the fi rst questions to be asked is ‘ can this be deterred? ’ Even when the answer is not very …

Russian disinformation has thus far proven to be unconvincing for most Dutch target audiences. This is the conclusion of the present chapter. Information and disinformation have become effective weapons in international politics. This is part of a development where the weapons and concepts used in deterrence …

Abstract Indeed, deterrence, as Freedman and Mazarr recount in this volume in respectively Chaps. 1 and 2, aims to dissuade an opponent from taking undesirable actions. Clear communication of demands (a red line for instance), coupled with a credible threat to in flict pain if necessary, and demonstration …